Document Detail


Expression of proliferating cell nuclear antigen in basal cell carcinomas and in squamous cell carcinomas of canine skin: correlation with mitotic index and histological features.
MedLine Citation:
PMID:  8578908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we evaluated the behaviour of proliferating cell nuclear antigen labelling index (PCNA-LI), mitotic index (MI) and histological features in ten basal cell carcinomas (BCC) and ten squamous cell carcinomas (SCC) of canine skin. PCNA-LI ranged from 2.1% to 4.8% in SCC and from 0.1% to 2.0% in BCC samples. A significant statistical correlation, between PCNA-LI and MI could be demonstrated only in SCC, but not in BCC samples. Furthermore, PCNA-LI was also significantly and consistently greater in the three BCC of solid type and in poorly differentiated SCC. PCNA-LI may provide additional criterion in evaluating the intrinsic malignancy and growth potential of the above tumours.
Authors:
P Maiolino; B Restucci; G De Vico
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Veterinärmedizin. Reihe A     Volume:  42     ISSN:  0514-7158     ISO Abbreviation:  Zentralbl Veterinarmed A     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-03-14     Completed Date:  1996-03-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0331323     Medline TA:  Zentralbl Veterinarmed A     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  339-43     Citation Subset:  IM    
Affiliation:
Dipartimento di Patologia, Profilassi e di Ispezione degli Alimenti, Facoltà di Medicina Veterinaria, Università degli studi di Napoli Federico II, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Basal Cell / chemistry,  pathology,  veterinary*
Carcinoma, Squamous Cell / chemistry,  pathology,  veterinary*
Dog Diseases / metabolism*,  pathology
Dogs
Mitotic Index
Proliferating Cell Nuclear Antigen / analysis*,  metabolism
Skin Neoplasms / chemistry,  pathology,  veterinary*
Chemical
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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