Document Detail


Expression and prognostic value of c-erbB-2 oncogene product in human phaeochromocytomas.
MedLine Citation:
PMID:  9279565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Amplification of c-erbB-2 proto-oncogene has been reported in endocrine tumours, but the results were unclear and no predictive prognostic value has been established in the case of phaeochromocytoma. We investigated the immunohistochemical expression of c-erbB-2 oncogene in 34 cases of human phaeochromocytoma (27 sporadic, seven familial type MEN (multiple endocrine neoplasm)) in order to find out if it could be used to differentiate sporadic and familial forms and whether c-erbB-2 expression is related to tumour biological behaviour. METHODS AND RESULTS: All the cases showed diffuse, generally heterogeneous, intracytoplasmic granular c-erbB-2 staining. The percentage of tumour cells expressing c-erbB-2 was used as the comparative variable. The percentage of c-erbB-2 positive cells had a statistically significant (P < 0.001) relationship with tumour aggressiveness, as manifested by the presence of distant metastasis or association with other malignant neoplasms. We also found significantly higher levels (P = 0.007) of c-erbB-2 overexpression in MEN phaeochromocytoma than in sporadic cases. CONCLUSIONS: These results clarify the important role of c-erbB-2 proto-oncogene in the pathogenesis of human phaeochromocytoma and confirm the unfavourable prognostic significance of c-erbB-2 expression.
Authors:
L Castilla-Guerra; A M Moreno; M C Fernández-Moreno; J C Utrilla; E Fernández; H Galera-Davison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  31     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-06     Completed Date:  1997-10-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Affiliation:
Department of Cytology and Histopathology, University of Seville, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Gland Neoplasms / metabolism*,  physiopathology
Adult
Child
Female
Humans
Immunohistochemistry
Male
Middle Aged
Pheochromocytoma / metabolism*,  physiopathology
Prognosis
Receptor, erbB-2 / metabolism*
Tumor Markers, Biological*
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; EC 2.7.10.1/Receptor, erbB-2

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