| Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation pattern. | |
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MedLine Citation:
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PMID: 9468318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the detailed expression pattern of the voltage-dependent potassium channel KV3.4 (rat homologue, Raw3) in mouse skeletal muscle. Using semi-quantitative RT-PCR, we show that its expression is detectable at embryonic day 17 and rises to adult levels within 2 weeks after birth. Expression is fiber type-dependent, with mRNA levels being 5-6-fold lower in the mixed slow/fast soleus muscle than in the fast tibialis anterior and extensor digitorum longus muscles. Fast muscles from myotonic mice exhibit low KV3.4 mRNA levels similar to those of wild-type soleus. In denervated extensor digitorum longus, KV3.4 expression declines to perinatal levels. We conclude that KV3.4 expression in mouse skeletal muscle is regulated by the pattern of excitation. |
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Authors:
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D Vullhorst; R Klocke; J W Bartsch; H Jockusch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 421 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-02-27 Completed Date: 1998-02-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 259-62 Citation Subset: IM |
Affiliation:
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Developmental Biology Unit, University of Bielefeld, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Mice Mice, Inbred BALB C Mice, Inbred C57BL Muscle Denervation Muscle Development Muscle Fibers, Skeletal / metabolism Muscle, Skeletal / growth & development, innervation, metabolism* Myotonia / metabolism Potassium Channels / biosynthesis*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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