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Expression of podoplanin is a rare event in sporadic gastrointestinal stromal tumors and does not influence prognosis.
MedLine Citation:
PMID:  22830405     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aims: Podoplanin overexpression is associated with worse prognosis in several human cancers. In gastrointestinal stromal tumors (GISTs) very few data on the expression of podoplanin exist, but it seems to be frequently overexpressed in pediatric/syndromic GISTs. We investigated podoplanin expression and its clinical relevance in a large series of sporadic GISTs. Methods: Podoplanin expression was determined immunohistochemically in 145 sporadic adult GISTs. Aneuploidies of 1p36 and 1q25 were investigated using FISH, and KIT and PDGFRA genes were investigated by sequencing. Results: Overexpression of podoplanin was observed in eight (5.6%) GISTs and no association with amplification of 1p36 or KIT or PDGFRA mutations was seen. The amount of podoplanin expression was not associated with clinical risk factors or patient survival. Conclusion: Overexpression of podoplanin is a rare event in sporadic GISTs and is not associated with amplification of 1p36 or with KIT or PDGFRA mutations, which indicates limited pathobiological or clinical relevance.
Authors:
Sebastian F Schoppmann; Anna Sophie Berghoff; Bettina Jesch; Johannes Zacherl; Nadine Nirtl; Gerd Jomrich; Florian Maroske; Berthold Streubel; Ildiko Mesteri; Peter Birner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Future oncology (London, England)     Volume:  8     ISSN:  1744-8301     ISO Abbreviation:  Future Oncol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256629     Medline TA:  Future Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  859-66     Citation Subset:  IM    
Affiliation:
Department of Surgery, Upper GI Research Unit, Medical University of Vienna, General Hospital, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
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