| Expression of platelet-derived growth factor and its receptors in spontaneous canine hemangiosarcoma and cutaneous hemangioma. | |
| | |
MedLine Citation:
|
PMID: 22419024 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Hemangiosarcoma (HSA) is a malignant neoplasia of vascular endothelial cells (ECs). Our previous report on the expression of vascular endothelial growth factor, basic fibroblast growth factor, and their receptors in canine HSA suggested an autocrine/ paracrine mechanism of tumor growth. However, the influence of other angiogenic growth factors in canine HSA was not elucidated; therefore, the expression of platelet-derived growth factor (PDGF) and its receptors was investigated by immunohistochemical analysis. Forty-six canine HSAs and 21 canine cutaneous hemangiomas (HAs) were analyzed. For immunohistochemistry, anti-PDGF-BB, anti-PDGFR-α, and anti-PDGFR-β antibodies were utilized as primary antibodies. Immunoreactivities were scored as strongly positive (>25% positive neoplastic cells), weakly positive (1-25% positive neoplastic cells), and negative if not staining at all. In cutaneous HA, 33.3% and 57.1% of cases were strongly and weakly positive, respectively, and 43.5% and 13.0% of HSAs were strongly and weakly positive for PDGF-BB, respectively. Moreover, 38.1% and 28.6% of cutaneous HAs cases were strongly and weakly positive, respectively, and 23.9% and 4.3% of HSAs cases were strongly and weakly positive, respectively, for PDGFR-α. Thirty-five HSAs cases (76.1%) were strongly positive, and the remaining 11 (23.9%) were weakly positive for PDGFR-β. In contrast, 18 (72.0%) cutaneous HAs were negative, and only 3 cases (12.0%) were weakly positive, for PDGFR-β. The proportion of strongly positive cases of HSAs was significantly higher than that of cutaneous HA for PDGFR-β (P<0.01), while PDGFR-α was highly expressed in cutaneous HA and may be related to pathogenesis of cutaneous HA. Therefore, PDGFR-β may be associated with the malignant nature of canine HSA. |
| | |
Authors:
|
S A Asa; A Murai; M Murakami; Y Hoshino; T Mori; K Maruo; A Khater; A El-Sawak; E A El-Aziz; T Yanai; H Sakai |
Related Documents
:
|
3204484 - Severe gingival damage after polysiloxane impression procedures. a case report. 23024384 - Corynebacterium pseudotuberculosis liver abscess in a mature alpaca (lama pacos). 8027894 - Treatment of delayed and nonunions of the humeral shaft using the seidel locking nail: ... 11642534 - Wide excision and free flap reconstruction of two cases with adult form of juvenile hya... 19817804 - Interobserver and intraobserver reproducibility in focal cortical dysplasia (malformati... 10812704 - Cutaneous histiocytic lymphangitis: an unusual manifestation of rheumatoid arthritis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Histology and histopathology Volume: 27 ISSN: 1699-5848 ISO Abbreviation: Histol. Histopathol. Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
|
Languages: eng Pagination: 601-7 Citation Subset: IM |
Affiliation:
|
Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prognostic significance of BAF57 expression in patients with endometrial carcinoma.
Next Document: Semiquantitative analysis of ECM molecules in the different cartilage layers in early and advanced o...