Document Detail

Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma.
MedLine Citation:
PMID:  16395714     Owner:  NLM     Status:  MEDLINE    
Cancer cell invasion is facilitated by extracellular matrix degrading proteases such as plasmin. We have studied the expression of plasminogen activator inhibitor-1 (PAI-1) and urokinase receptor (uPAR) together with the gamma2-chain of laminin-5 (lam-gamma2) by immunohistochemistry in 20 cases with incipient oral squamous cell carcinoma (SCC). PAI-1-positive neoplastic cells located at the tip of the putative invasive front of grade 1 (incipient) carcinoma were seen in 16 of the 20 cases (75%), whereas adjacent normal and dysplastic epithelium was PAI-1-negative. Clusters of putative invasive neoplastic cells located in the lamina propria were PAI-1-positive in areas with grade 2 incipient carcinoma as were invasive cancer cells in areas of grade 3-4 invasive carcinoma. uPAR immunoreactivity was strongly expressed in numerous stromal cells in the carcinoma area in all 20 lesions, while a few uPAR-positive stromal cells were found in areas with normal and dysplastic epithelium. uPAR-positive neoplastic cell islands located at the front of the lesions were seen in 15 of the 20 cases. The expression pattern of lam-gamma2 was very similar to that of PAI-1; however, lam-gamma2-positive neoplastic cells were only detected in 11 of the 20 cases (55%) in areas of grade 1 incipient carcinoma. Direct comparison of the 3 components revealed colocalization in neoplastic cell islands in both incipient and invasive SCC. Our results suggest that PAI-1 is a novel potential marker of initial invasion in oral SCC, and that the coordinated expression of PAI-1 with uPAR and lam-gamma2 sustain the features of the early invasive cancer cells.
Pia Lindberg; Ake Larsson; Boye Schnack Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  118     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-04-03     Completed Date:  2006-05-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2948-56     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Wiley-Liss, Inc.
Department of Oral Pathology, Center for Oral Health Science, Malmö University, Sweden.
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MeSH Terms
Carcinoma, Squamous Cell / chemistry*
Gene Expression Regulation, Neoplastic
Immunoenzyme Techniques
Laminin / analysis*,  immunology
Mouth Mucosa / chemistry
Mouth Neoplasms / chemistry*
Plasminogen Activator Inhibitor 1 / analysis*,  immunology
Receptors, Cell Surface / analysis*,  immunology
Receptors, Urokinase Plasminogen Activator
Serine Proteinase Inhibitors / analysis
Tumor Markers, Biological / analysis*,  immunology
Reg. No./Substance:
0/LAMC2 protein, human; 0/Laminin; 0/PLAUR protein, human; 0/Plasminogen Activator Inhibitor 1; 0/Receptors, Cell Surface; 0/Receptors, Urokinase Plasminogen Activator; 0/Serine Proteinase Inhibitors; 0/Tumor Markers, Biological

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