Document Detail

Expression patterns of MDA-9/syntenin during development of the mouse embryo.
MedLine Citation:
PMID:  23180153     Owner:  NLM     Status:  MEDLINE    
Melanoma differentiation associated gene-9 (MDA-9)/syntenin is a PDZ domain-containing adaptor protein involved in multiple diverse cellular processes including organization of protein complexes in the plasma membrane, intracellular trafficking and cell surface targeting, synaptic transmission, and cancer metastasis. In the present study, we analyzed the expression pattern of MDA-9/syntenin during mouse development. MDA-9/syntenin was robustly expressed with tight regulation of its temporal and spatial expression during fetal development in the developing skin, spinal cord, heart, lung and liver, which are regulated by multiple signaling pathways in the process of organogenesis. Recent studies also indicate that MDA-9/syntenin is involved in the signaling pathways crucial during development such as Wnt, Notch and FGF. Taken together, these results suggest that MDA-9/syntenin may play a prominent role during normal mouse development in the context of cell proliferation as well as differentiation through modulating multiple signaling pathways as a crucial adaptor protein. Additionally, temporal regulation of MDA-9/syntenin expression may be required during specific stages and in specific tissues during development.
Hyun Yong Jeon; Swadesh K Das; Santanu Dasgupta; Luni Emdad; Devanand Sarkar; Sung-Hoon Kim; Seok-Geun Lee; Paul B Fisher
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-20
Journal Detail:
Title:  Journal of molecular histology     Volume:  44     ISSN:  1567-2387     ISO Abbreviation:  J. Mol. Histol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2013-11-04     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101193653     Medline TA:  J Mol Histol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-66     Citation Subset:  IM    
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MeSH Terms
Embryonic Development* / genetics
Gene Expression Profiling*
Hair Follicle / embryology,  metabolism
Heart / embryology
Liver / embryology,  metabolism
Lung / embryology,  metabolism
Myocardium / enzymology,  metabolism
Skin / embryology,  metabolism
Spinal Cord / embryology,  metabolism
Syntenins / genetics,  metabolism*
Grant Support
R01 CA097318/CA/NCI NIH HHS; R01 CA138540/CA/NCI NIH HHS; R05 CA097318/CA/NCI NIH HHS
Reg. No./Substance:

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