Document Detail


Expression pattern of the transforming growth factor β signaling genes in human peripheral blood mononuclear cells after exercise-inflammatory aspects.
MedLine Citation:
PMID:  22915245     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The present study has focused on the identification of differences between the expression pattern of TGF-β signaling pathway genes in athletes after exercise. MATERIALS AND METHODS: The study group consisted of three healthy cyclists, which were collected pre-exercise, immediately postexercise, and after 15 min of recovery. The analysis of the expression profile of genes related to the TGF-β signal transduction pathway was performed in peripheral blood mononuclear cells using HG-U133A oligonucleotide microarrays. RESULTS: A significant differential gene expression was recorded for RUNX3, TGFBR3, MLC1, and GRB2. CONCLUSIONS: The effect of physical exercise on immune response may be essential for human health. Moreover, alterations of TGF-β signaling can be involved in the process of adaptation of human organism to physical exertion. Am. J. Hum. Biol., 2012. © 2012 Wiley Periodicals, Inc.
Authors:
Magdalena Kimsa; Barbara Strzalka-Mrozik; Malgorzata Kimsa; Joanna Gola; Aleksandra Kochanska-Dziurowicz; Aleksandra Zebrowska; Grazyna Janikowska; Urszula Mazurek; Szymon Jonczyk
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-22
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  -     ISSN:  1520-6300     ISO Abbreviation:  Am. J. Hum. Biol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Molecular Biology, Medical University of Silesia, Sosnowiec, Poland. magdakimsa@gmail.com.
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