Document Detail


Expression pattern of integrin beta 1 subunit in Purkinje cells of rat and cerebellar mutant mice.
MedLine Citation:
PMID:  8915827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We found that integrin beta 1 subunit (INT beta 1)-immunoreactive Purkinje cells first appeared caudally at postnatal day (PD) 6 of rat and most Purkinje cells gradually became positive by PD 12. The expression of INT beta 1 was then suppressed in some of these cells, so that the positive Purkinje cells in the adult were organized into parasagittal bands interposed by negative cells throughout the vermis and hemispheres. When Purkinje cells were deprived of their climbing fiber innervation by inferior cerebellar pedunculotomy or by transplantation of cerebellar anlagen into the anterior eye chamber, the subsequent patterning of INT beta 1-positive Purkinje cells was not changed. In both reeler and weaver mice, the INT beta 1-positive parasagittal bands were observed, however, the Purkinje cells in the staggerer mice did not express INT beta 1 at any stage. These data suggest that the expression of INT beta 1 in Purkinje cells is genetically programmed in the developing cerebellum, and that the afferent synaptic inputs by climbing and parallel fibers are not prerequisites for INT beta 1 expression in Purkinje cells. Therefore, the unique distribution patterns of INT beta 1-positive Purkinje cells provides a new marker for postnatal development of rodent cerebella.
Authors:
S Murase; Y Hayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  375     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-37     Citation Subset:  IM    
Affiliation:
Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
3T3 Cells
Animals
Antigens, CD29 / analysis*,  genetics
Brain Mapping*
Cerebellum / chemistry*,  cytology,  growth & development
Immunohistochemistry
In Situ Hybridization
Mice
Mice, Neurologic Mutants
Nerve Fibers / physiology
Purkinje Cells / chemistry*
RNA, Messenger / analysis
Rats
Chemical
Reg. No./Substance:
0/Antigens, CD29; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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