Document Detail

Expression pattern of JunD after acute or chronic L-DOPA treatment: comparison with deltaFosB.
MedLine Citation:
PMID:  17055656     Owner:  NLM     Status:  MEDLINE    
In this study, we have used 6-hydroxydopamine-lesioned rats to examine changes in striatal junD and fosB/deltafosB expression induced by acute and chronic treatment with L-DOPA (5 and 15 days). Changes at the protein levels were studied using Western immunoblotting while mRNA changes were compared using in situ hybridization histochemistry. We observed a significant increase in the level of deltaFosB proteins after chronic treatment with L-DOPA, an effect that was not observed for JunD proteins. In addition, the upregulation of deltaFosB was already present after an acute treatment but increased upon chronic treatment. By contrast, junD and deltafosB mRNA were both upregulated significantly above control levels after an acute injection of L-DOPA. In conclusion, this study suggests a differential expression pattern of junD and deltafosB in a rat model of L-DOPA-induced dyskinesia. The upregulation of deltaFosB protein, but not JunD, is likely to reflect an increased stability of the deltaFosB proteins without ongoing enhanced transcription of the encoding genes.
B Valastro; M Andersson; H S Lindgren; M A Cenci
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-19
Journal Detail:
Title:  Neuroscience     Volume:  144     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  198-207     Citation Subset:  IM    
Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, BMC F11, Lund 221 84, Sweden.
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MeSH Terms
Antiparkinson Agents / pharmacology*
Blotting, Western
Gene Expression Regulation / drug effects
In Situ Hybridization
Levodopa / pharmacology*
Neostriatum / drug effects,  metabolism
Oxidopamine / toxicity
Proto-Oncogene Proteins c-fos / biosynthesis*
Proto-Oncogene Proteins c-jun / biosynthesis*
RNA, Messenger / biosynthesis,  genetics
Rats, Sprague-Dawley
Reg. No./Substance:
0/Antiparkinson Agents; 0/Fosb protein, rat; 0/Levodopa; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger; 1199-18-4/Oxidopamine

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