Document Detail


Expression of parathyroid hypertensive factor in hypertensive primary hyperparathyroid patients.
MedLine Citation:
PMID:  8193726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is frequently associated with primary hyperparathyroidism, yet the mechanism of such hypertension is unknown. Parathyroid hypertensive factor (PHF) is a circulating hypertensive factor found in a proportion of human essential hypertensive patients as well as in spontaneously hypertensive rats (SHR). In the latter case, PHF has been shown to be secreted by the parathyroid gland. The purpose of this study was to determine if PHF expression might be responsible for the hypertension seen in primary hyperparathyroidism. Ten hypertensive and 10 normotensive primary hyperparathyroid patients underwent measurement of blood pressure and PHF pre- and post-parathyroidectomy. Cases reported are those of parathyroid adenomas. There were no significant differences between the hypertensive and normotensive groups preoperatively except that 9 out of 10 of the hypertensive group had significant PHF levels (mean 11 +/- 2 mm Hg vs 0.6 +/- 2 mm Hg, respectively, p = 0.003). Post-operative change in mean arterial pressure could be predicted by pre-operative PHF level, with all PHF-positive patients showing a fall in blood pressure (r = -0.73, p < 0.01). Post-operatively, PHF was undetectable in PHF-positive patients. These results suggest that the parathyroid gland can express PHF in humans and that such expression may be responsible for a proportion of the high reported incidence of hypertension in primary hyperparathyroidism.
Authors:
R Z Lewanczuk; P K Pang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  2     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1994-06-30     Completed Date:  1994-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  22-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Alberta, Edmonton, Canada.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Biological Assay
Biological Factors / blood*
Blood Pressure / physiology
Calcium / metabolism
Female
Humans
Hyperparathyroidism / blood*,  complications,  metabolism
Hypertension / blood*,  complications,  physiopathology
Male
Middle Aged
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Biological Factors; 0/parathyroid hypertensive factor; 7440-70-2/Calcium
Comments/Corrections
Comment In:
Blood Press. 1993 Mar;2(1):4-5   [PMID:  8193729 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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