Document Detail

Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction.
MedLine Citation:
PMID:  11243862     Owner:  NLM     Status:  MEDLINE    
Recent studies have shown that oxidative stress plays an important role in cardiovascular diseases. NADPH oxidase is one of the major sources of superoxide anions and a candidate for the initiation and development of atherosclerosis, which involves the remodeling of vasculature. However, the relevance of NADPH oxidase in ventricular remodeling has not been well-characterized. This is the first report showing that the expression of p22-phox and gp91-phox, essential components of NADPH oxidase, are increased in the infarcted sites after myocardial infarction. The levels of thiobarbituric acid reactive substance, which indicates the lipid peroxidation level, and nuclear factor-kappaB (NF-kappaB) DNA binding activity are also increased in infarcted sites. Our results suggest that the increased expression of NADPH oxidase may have an effect on left ventricular remodeling by increasing the redox-sensitive NF-kappaB DNA binding activity as well as the lipid peroxidation level.
T Fukui; M Yoshiyama; A Hanatani; T Omura; J Yoshikawa; Y Abe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  281     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-13     Completed Date:  2001-04-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1200-6     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Department of Pharmacology, Kagawa Medical University, Kagawa, Japan.
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MeSH Terms
Atrial Natriuretic Factor / biosynthesis,  genetics
DNA / metabolism
Heart Ventricles / metabolism
Lipid Peroxidation
Membrane Glycoproteins / biosynthesis,  genetics*
Membrane Transport Proteins*
Myocardial Infarction / metabolism*
NADPH Dehydrogenase / biosynthesis,  genetics*
NADPH Oxidase / metabolism*
NF-kappa B / metabolism
Phosphoproteins / biosynthesis,  genetics*
RNA, Messenger / biosynthesis
Rats, Wistar
Transcriptional Activation
Reg. No./Substance:
0/CYBB protein, human; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/NF-kappa B; 0/Phosphoproteins; 0/RNA, Messenger; 85637-73-6/Atrial Natriuretic Factor; 9007-49-2/DNA; EC protein, human; EC Oxidase; EC Dehydrogenase

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