| Expression of oxidative stress-response genes is not activated in the prefrontal cortex of patients with depressive disorder. | |
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MedLine Citation:
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PMID: 20800905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that the oxidative stress consistently detected in the peripheral blood of patients with depressive disorder impacts on the functionally relevant brain region, the expression level of nine major genes of the stress response and repair systems has been quantified in the prefrontal cortex of 24 depressive and 12 control subjects. These genes were: superoxide dismutase (SOD1), SOD2, catalase (CAT), gluthatione peroxidase 1 (GPx1), 8-oxoguanine DNA glycosylase (OGG1), nei-like 1 (NEIL1), methionine sulphoxide reductase A (MSRA), telomere repeat-binding factor 2 (TERF2) and C-FOS. Telomere length (a maker of chronic exposure to oxidative stress) has been measured in the DNA of the occipital cortex. No significant difference has been found between the compared groups. It must be concluded that the pathogenic role of the oxidative stress in the cerebral mechanism of depression cannot be inferred from the alteration of peripheral parameters. |
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Authors:
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Jean-Raymond Teyssier; Sylviane Ragot; Jean-Christophe Chauvet-Gélinier; Benoit Trojak; Bernard Bonin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Psychiatry research Volume: 186 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-11 Completed Date: 2011-05-12 Revised Date: 2012-05-28 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 244-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Genetics, University Hospital, PTB, 21070 Dijon, France. teyssier@u-bourgogne.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Catalase / genetics Child Child, Preschool DNA Glycosylases / genetics Depression / genetics*, pathology* Female Glutathione Peroxidase / metabolism Humans Male Methionine Sulfoxide Reductases / genetics Oxidative Stress / genetics* Prefrontal Cortex / metabolism* Proto-Oncogene Proteins c-fos / genetics Superoxide Dismutase / genetics Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-fos; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.4.-/Methionine Sulfoxide Reductases; EC 1.8.4.11/methionine sulfoxide reductase; EC 3.2.2.-/DNA Glycosylases; EC 3.2.2.-/NEIL1 protein, human; EC 3.2.2.-/oxoguanine glycosylase 1, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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