Document Detail

Expression of oxidative stress in metastatic retinoblastoma- a comparative study.
MedLine Citation:
PMID:  22864033     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare oxidative stress between primary retinoblastoma and retinoblastoma with distant metastasis.
PATIENTS AND METHODS: Forty consecutive patients presented with primary retinoblastoma and the same number of patients presented with distant metastasis, attending the outpatient department of our hospital between August 2002 and April 2005. All the patients with retinoblastoma underwent a standard metastasis workup and were subsequently categorized into two groups (without metastasis and with metastasis).Venous blood samples were drawn from each patient. After proper centrifugation, serum was collected and antioxidant enzymes and reactive oxygen species (ROS) were assayed.
MAIN OUTCOME MEASURES: Serum collected from the patients was subjected to biochemical assay of the antioxidant enzymes (superoxide dismutase, catalase and peroxidise) and ROS to determine any difference in enzyme activity between the two groups.
RESULTS: Antioxidant levels were found to be less in the metastasis group as compared to the primary intraocular retinoblastoma group(p less than 0.05).Mean ROS activity was found to be increased in metastatic group (p less than 0.05).
CONCLUSION: The decreased antioxidant enzymes level along with increased ROS activity in patients with metastatic retinoblastoma reflect increased oxidative stress as compared to primary intraocular retinoblastoma patients.
S Mukhopadhyay; J Dutta; R Raut; H Datta; A K Bhattacharyay
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH     Volume:  4     ISSN:  2072-6805     ISO Abbreviation:  Nepal J Ophthalmol     Publication Date:    2012 Jul-Dec
Date Detail:
Created Date:  2012-08-06     Completed Date:  2013-07-18     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101505288     Medline TA:  Nepal J Ophthalmol     Country:  Nepal    
Other Details:
Languages:  eng     Pagination:  271-6     Citation Subset:  IM    
Copyright Information:
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MeSH Terms
Catalase / blood*
Follow-Up Studies
Oxidative Stress / physiology*
Peroxidase / blood*
Reactive Oxygen Species / blood*
Retinal Neoplasms / blood*,  pathology
Retinoblastoma / blood*,  secondary
Retrospective Studies
Superoxide Dismutase / blood*
Tumor Markers, Biological / blood
Reg. No./Substance:
0/Reactive Oxygen Species; 0/Tumor Markers, Biological; EC; EC; EC Dismutase

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