Document Detail

Expression of outer surface proteins A and C of Borrelia afzelii in Ixodes ricinus ticks and in the skin of mice.
MedLine Citation:
PMID:  9638876     Owner:  NLM     Status:  MEDLINE    
Several studies have described changes in the expression of proteins, especially of OspA and OspC, of B. burgdorferi sensu stricto during tick feeding. In this study, the expression of OspA and OspC of B. afzelii in unfed and feeding I. ricinus nymphs and in the subsequent adults was followed by means of the immunofluorescence test. Spirochaetes expressing OspA and OspC were observed in 70% and 80%, respectively of the unfed nymphs. In feeding and in fully engorged ticks, spirochaetes expressed OspC, while OspA disappeared 24 hours after the beginning of the blood meal. Spirochaetes expressing OspC in salivary glands were observed in one engorged tick. After molting, in unfed adults spirochaetes again expressed OspA and OspC but did so less frequently (6% and 13%, respectively). The mouse strain (AKR/N or BALB/C) on which ticks had their infectious blood meal influenced OspC expression in the following tick stage. In the skin of AKR/N mice, at the tick feeding site, B. afzelii expressed OspC only, as was shown by immunostaining.
S Leuba-Garcia; R Martinez; L Gern
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zentralblatt für Bakteriologie : international journal of medical microbiology     Volume:  287     ISSN:  0934-8840     ISO Abbreviation:  Zentralbl. Bakteriol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-23     Completed Date:  1998-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203851     Medline TA:  Zentralbl Bakteriol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  475-84     Citation Subset:  IM    
Institut de Zoologie, University of Neuchâtel, Switzerland.
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MeSH Terms
Antigens, Bacterial*
Antigens, Surface / biosynthesis*
Bacterial Outer Membrane Proteins / biosynthesis*
Bacterial Vaccines
Borrelia / metabolism*
Ixodes / metabolism*
Mice, Inbred AKR
Mice, Inbred BALB C
Skin / metabolism*
Reg. No./Substance:
0/Antigens, Bacterial; 0/Antigens, Surface; 0/Bacterial Outer Membrane Proteins; 0/Bacterial Vaccines; 0/Lipoproteins; 0/OspA protein; 0/OspC protein

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