| EXPRESSION AND NUTRITIONAL REGULATION OF THE (PRO)RENIN RECEPTOR IN RAT VISCERAL ADIPOSE TISSUE. | |
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MedLine Citation:
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PMID: 21483231 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Early life nutritional environment plays an important role in the development of visceral adipose tissue and interacts with nutritional regulations in adulthood, leading to metabolic dysregulations. Aim We hypothesized that the renin-angiotensin system may play a role in the programming-induced development of visceral adipose tissue. Material and methods We studied, using a model of programming of overweight and glucose intolerance, obtained by post-natal overfeeding with consecutive high-fat diet, the status of plasma renin activity and mesenteric adipose renin-angiotensin system, including the recently identified (pro)renin receptor, in adult rats. Results Post-natal overfeeding or high-fat feeding lead to overweight with increased visceral fat mass and adipocytes surface. When both paradigms were associated, adipocytes surface showed a disproportionate increase. A strong immunoreactivity for (pro)renin receptor was found in stromal cells. Plasma renin activity increased in programmed animals whereas (pro)renin receptor expressing cells density was stimulated by high-fat diet. There was a positive, linear relationship between plasma renin activity and (pro)renin receptor expressing cells density and adipocytes surface. Conclusions Our experiments demonstrate that association of post-natal overfeeding and high-fat diet increased plasma renin activity and adipose (pro)renin receptor expression. Such phenomenon could explain, at least in part, the associated disproportionate adipocytes hypertrophy and its accompanying increased glucose intolerance. |
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Authors:
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V Achard; V Tassistro; S Boullu-Ciocca; M Grino |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-6 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratoire d'Hématologie, Université de la Méditerranée, Marseille, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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