Document Detail

Expression of nuclear retinoic acid receptor in peripheral blood mononuclear cells (PBMC) of healthy subjects.
MedLine Citation:
PMID:  12479981     Owner:  NLM     Status:  MEDLINE    
In vertebrates, both nuclear all-trans and 9-cis retinoic acid receptors (RAR and RXR) belonging to the steroid/thyroid/retinoid nuclear receptor superfamily play a crucial role in the vitamin A action. Qualitative analysis of all known RAR or RXR subtypes in both pooled and non-pooled peripheral blood mononuclear cells (PBMC) from healthy human subjects has been performed by reverse transcription and polymerase chain reaction (RT-PCR). Our data, based on qualitative RT-PCR analysis has shown that human PBMC are capable to express RAR alpha, RAR gamma, RXR alpha, and RXR beta.
L Szabova; D Macejova; M Dvorcakova; S Mostbock; S Blazickova; S Zorad; S Walrand; N Cardinault; M P Vasson; E Rock; J Brtko
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  72     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-13     Completed Date:  2003-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  831-6     Citation Subset:  IM    
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovak Republic.
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MeSH Terms
Cell Nucleus / genetics,  metabolism*
DNA Primers / chemistry
Electrophoresis, Agar Gel
Leukocytes, Mononuclear / metabolism*
RNA, Messenger / metabolism
Receptors, Retinoic Acid / classification,  genetics,  metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/DNA Primers; 0/RNA, Messenger; 0/Receptors, Retinoic Acid

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