| Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines. | |
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MedLine Citation:
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PMID: 21461611 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The epigenetic dysregulation of tumor suppressor genes plays an important role in many cancers, including hepatocellular carcinoma (HCC). In this study, we identified a new gene, family with sequence similarity 43, member B (FAM43B), based on a previous genome-wide approach. FAM43B was significantly downregulated in 60% (24/40) HCC specimens as compared to non-HCC livers. Enforced FAM43B overexpression could suppress cell growth and colony formation in vitro, and induce cell cycle delay, whereas FAM43B knockdown enhanced cell growth. The expression level of FAM43B was found related to the methylation level of FAM43B promoter in HCC cell lines and HCC specimens. The collective data suggest that the expression of FAM43B was regulated by methylation and the epigenetic silencing of FAM43B could contribute to HCC tumorigenesis by regulating cell proliferation. |
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Authors:
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Xiao Xu; Rui-Fang Liu; Bing-Bing Wan; Wen-Ming Xing; Jian Huang; Ze-Guang Han |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-2 |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: - ISSN: 1573-4919 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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National Human Genome Center, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui-Jin II Road, Shanghai, 200025, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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