Document Detail

Expression of nitric oxide synthase-2 in cutaneous squamous cell carcinoma of the head and neck.
MedLine Citation:
PMID:  12054707     Owner:  NLM     Status:  MEDLINE    
Nitric oxide (NO) has a pivotal role in angiogenesis. The expression of NO synthase (NOS2) is down-regulated in basal cell skin cancer but we know of no studies that have investigated its expression in the more aggressive squamous cell skin carcinoma. This immunohistochemical study assessed NOS2 expression in 37 cases of head and neck squamous cell skin carcinoma. NOS2 expression was located in cells of the basal cell layer of epidermis, but was significantly increased in tumour epithelium. No correlations were found between NOS2 expression and tumour size or degree of tumour differentiation. The raised NO concentrations in these tumours may provide one explanation for their more aggressive behaviour than that of the slower-growing basal cell carcinoma.
P A Brennan; T Umar; G I Smith; C H Lo; S Tant
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of oral & maxillofacial surgery     Volume:  40     ISSN:  0266-4356     ISO Abbreviation:  Br J Oral Maxillofac Surg     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-10     Completed Date:  2002-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405235     Medline TA:  Br J Oral Maxillofac Surg     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  191-4     Citation Subset:  D; IM    
Copyright Information:
Copyright 2002 The British Association of Oral and Maxillofacial Surgeons.
Specialist Registrar in Oral and Maxillofacial Surgery, Poole General Hospital, Poole, Dorset, UK.
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MeSH Terms
Aged, 80 and over
Antibodies, Monoclonal / diagnostic use
Carcinoma, Squamous Cell / enzymology*,  genetics,  pathology
Chi-Square Distribution
Coloring Agents / diagnostic use
Cytoplasm / enzymology
Epidermis / enzymology,  pathology
Epithelium / enzymology,  pathology
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms / enzymology*,  genetics,  pathology
Immunoenzyme Techniques
Keratinocytes / enzymology,  pathology
Middle Aged
Neovascularization, Pathologic / enzymology
Nitric Oxide Synthase / analysis*,  genetics
Nitric Oxide Synthase Type II
Skin Neoplasms / enzymology*,  genetics,  pathology
Statistics, Nonparametric
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Coloring Agents; EC Oxide Synthase; EC Oxide Synthase Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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