| Expression of neurotrophin genes in the brain of senescence-accelerated mouse (SAM) during postnatal development. | |
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MedLine Citation:
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PMID: 8069696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared the expression patterns of neurotrophin genes in the brain of senescence-accelerated mouse (SAMP8) which shows age-related impairment of learning behavior, with SAMR1 control which shows normal aging. By Northern blot analysis, NT-3 mRNA levels in the cortex were higher in SAMP8 than in SAMR1 mice during development, whereas in the midbrain, hippocampus and forebrain, NT-3 expression levels in SAMP8 were lower than those in SAMR1. At early stages, although NGF mRNA levels in SAMP8 were lower than those in SAMR1, BDNF mRNA levels were almost equivalent in both strains. By in situ hybridization analysis, NT-3 mRNA signals in the CA1 and CA2 regions in SAMP8 were shown to be reduced at early stages. However, BDNF mRNA signals were almost equivalent in both SAMR1 and SAMP8. |
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Authors:
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Y Kaisho; M Miyamoto; O Shiho; H Onoue; Y Kitamura; S Nomura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research Volume: 647 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-09-26 Completed Date: 1994-09-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 139-44 Citation Subset: IM |
Affiliation:
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Discovery Res. Labs., Takeda Chem. Ind. Ltd., Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Animals, Newborn / growth & development* Blotting, Northern Brain / growth & development, metabolism, physiopathology* Brain-Derived Neurotrophic Factor Gene Expression* In Situ Hybridization Male Mice Mice, Mutant Strains / genetics* Nerve Growth Factors / genetics*, metabolism Nerve Tissue Proteins / genetics, metabolism Neurotrophin 3 RNA, Messenger / metabolism Reference Values Time Factors Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor; 0/Nerve Growth Factors; 0/Nerve Tissue Proteins; 0/Neurotrophin 3; 0/RNA, Messenger |
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