| Expression of myogenic regulating factors, Myogenin and MyoD, in two canine botryoid rhabdomyosarcomas. | |
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MedLine Citation:
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PMID: 15133178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myogenin and MyoD regulate the development of skeletal muscle, and their expressions are specific to the stages of myogenesis. Therefore, these myogenic regulatory proteins could be considered as sensitive and specific markers for rhabdomyosarcoma. In this report we investigated the immunohistochemical reactivities of myogenin and MyoD in two canine bladder botryoid rhabdomyosarcomas that were different in the degree of differentiation. MyoD was stained in the Ki-67 antigen-positive undifferentiated mesenchymal cells, which had proliferative activity similar to myoblasts differentiated from mesoblasts. In contrast, multinucleated neoplastic cells were positive for myogenin and alpha-sarcomeric actin but not for Ki-67 antigen, similar to the myotubes differentiated from myoblastic cells. The expressions of myogenin and MyoD were closely correlated to the histologic features of myogenic neoplastic cells. |
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Authors:
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M Kobayashi; H Sakai; A Hirata; K Yonemaru; T Yanai; K Watanabe; K Yamazoe; T Kudo; T Masegi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Veterinary pathology Volume: 41 ISSN: 0300-9858 ISO Abbreviation: Vet. Pathol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-10 Completed Date: 2004-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0312020 Medline TA: Vet Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 275-7 Citation Subset: IM |
Affiliation:
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Department of Veterinary Pathology and Surgery, Faculty of Agriculture, Gifu University 1-1 Yanagido, Gifu 501-1193, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins Animals Dog Diseases / metabolism* Dogs Gene Expression Regulation, Neoplastic* Immunohistochemistry Ki-67 Antigen MyoD Protein / metabolism* Myogenic Regulatory Factors / metabolism* Myogenin / metabolism* Rhabdomyosarcoma / metabolism, veterinary* Urinary Bladder Neoplasms / metabolism, veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Ki-67 Antigen; 0/MyoD Protein; 0/Myogenic Regulatory Factors; 0/Myogenin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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