Document Detail

Expression of myogenic regulating factors, Myogenin and MyoD, in two canine botryoid rhabdomyosarcomas.
MedLine Citation:
PMID:  15133178     Owner:  NLM     Status:  MEDLINE    
Myogenin and MyoD regulate the development of skeletal muscle, and their expressions are specific to the stages of myogenesis. Therefore, these myogenic regulatory proteins could be considered as sensitive and specific markers for rhabdomyosarcoma. In this report we investigated the immunohistochemical reactivities of myogenin and MyoD in two canine bladder botryoid rhabdomyosarcomas that were different in the degree of differentiation. MyoD was stained in the Ki-67 antigen-positive undifferentiated mesenchymal cells, which had proliferative activity similar to myoblasts differentiated from mesoblasts. In contrast, multinucleated neoplastic cells were positive for myogenin and alpha-sarcomeric actin but not for Ki-67 antigen, similar to the myotubes differentiated from myoblastic cells. The expressions of myogenin and MyoD were closely correlated to the histologic features of myogenic neoplastic cells.
M Kobayashi; H Sakai; A Hirata; K Yonemaru; T Yanai; K Watanabe; K Yamazoe; T Kudo; T Masegi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  41     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-10     Completed Date:  2004-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-7     Citation Subset:  IM    
Department of Veterinary Pathology and Surgery, Faculty of Agriculture, Gifu University 1-1 Yanagido, Gifu 501-1193, Japan.
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MeSH Terms
Dog Diseases / metabolism*
Gene Expression Regulation, Neoplastic*
Ki-67 Antigen
MyoD Protein / metabolism*
Myogenic Regulatory Factors / metabolism*
Myogenin / metabolism*
Rhabdomyosarcoma / metabolism,  veterinary*
Urinary Bladder Neoplasms / metabolism,  veterinary*
Reg. No./Substance:
0/Actins; 0/Ki-67 Antigen; 0/MyoD Protein; 0/Myogenic Regulatory Factors; 0/Myogenin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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