| Expression of myeloid markers lacks prognostic impact in children treated for acute lymphoblastic leukemia: Italian experience in AIEOP-ALL 88-91 studies. | |
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MedLine Citation:
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PMID: 9680347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The importance of coexpression of myeloid antigens in childhood acute lymphoblastic leukemia (ALL) has long been debated; results are conflicting. We studied children with ALL treated at Italian Association for Pediatric Hematology-Oncology (AIEOP) institutions over 6 years with Berlin-Frankfurt-Muenster (BFM)-based protocols and have analyzed the incidence of coexpression of six MyAg (CD11b, CD13, CD14, CD15, CD33, CD65w) to determine its prognostic impact. Criteria for MyAg coexpression (MyAg+ALL) included positivity to one or more MyAg on at least 20% of blasts and confirmation of coexpression at double-fluorescence analysis. A total of 291 of 908 cases were MyAg+ALL (32%). Incidence was similar in B-ALL and T-ALL; among common, pre-B, and pre-pre-B-ALL. CD13 and CD33 were most common. Patients with MyAg+ALL had presenting features similar to MyAg-ALL. They entered standard or intermediate risk protocols more frequently and had better prednisone response, but similar complete remission rates. Six-year event-free survival (EFS) was 69.0% in 291 MyAg+ALL cases and 65.3% in 617 MyAg-ALL cases, without significant difference. Cases expressing two or more MyAg presented similar clinical features and treatment response. MyAg+ALL had worse EFS only in infants (0% v 47%) (P = .01). Therefore, in this series of homogeneously diagnosed and treated ALL, coexpression of MyAg was not associated with prognostic significance, without relevance for clinical purposes or for patient stratification, except for infants. |
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Authors:
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M C Putti; R Rondelli; M G Cocito; M Aricó; L Sainati; V Conter; C Guglielmi; A Cantú-Rajnoldi; R Consolini; A Pession; L Zanesco; G Masera; A Biondi; G Basso |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood Volume: 92 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-08-27 Completed Date: 1998-08-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 795-801 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 1998 by The American Society of Hematology. |
Affiliation:
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Dipartimento di Pediatria, Universitá di Padova, Padova; III Clinica Pediatrica, Universitá di Bologna, Bologna, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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analysis* Antineoplastic Combined Chemotherapy Protocols / therapeutic use Bone Marrow / chemistry*, pathology Child Child, Preschool Combined Modality Therapy Cranial Irradiation Disease-Free Survival Female Fluorescent Antibody Technique, Indirect Follow-Up Studies Humans Immunophenotyping Infant Italy Male Neoplasm Proteins / analysis* Neoplastic Stem Cells / chemistry, pathology Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy, metabolism, mortality*, radiotherapy Prognosis Proportional Hazards Models Remission Induction Risk Factors Survival Analysis Treatment Outcome Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Neoplasm Proteins; 0/Tumor Markers, Biological |
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