Document Detail

Expression of mutant genes in mouse aggregation chimeras. 4. The aphakia gene
MedLine Citation:
PMID:  4047586     Owner:  NLM     Status:  MEDLINE    
Analysis of aphakia (ak) gene expression in ak/ak C/C in equilibrium +/+ c/c experimental chimaeras has shown that the ak gene acts in the lens rudiment cells blocking it differentiation. In the lens of 12 day old ak/ak C/C in equilibrium +/+ c/c chimaeric embryos undifferentiated ak/ak cells were present among the normally differentiating fibres. In 14 and 18 day old chimaeric embryos and 20 day old chimaeric mice ak/ak cells are located under the lens epithelium and the capsule of posterior lens half. In the locations of ak/ak cells on the posterior lens surface capsule breaks resulted in the extrusion of lens material into the secondary eye cavity. In all studied chimaeric embryos the lens structure is more similar to that in the normal embryos, than in ak/ak embryos. This suggests that in the developing chimaeric lens ak/ak cells are sorted out as the development proceeds. The proliferation rate of +/+ cells appears to be higher than that of ak/ak cells.
B V Koniukhov; S D Kupriianov
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article    
Journal Detail:
Title:  Ontogenez     Volume:  16     ISSN:  0475-1450     ISO Abbreviation:  Ontogenez     Publication Date:    1985 Jul-Aug
Date Detail:
Created Date:  1985-11-04     Completed Date:  1985-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0341527     Medline TA:  Ontogenez     Country:  USSR    
Other Details:
Languages:  rus     Pagination:  358-64     Citation Subset:  IM    
Vernacular Title:
Izuchenie ékspressii mutantnykh genov u agregatsionnykh khimer myshi. 4. Gen aphakia.
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MeSH Terms
Aphakia / genetics*
Cell Differentiation
Cell Division
Culture Techniques
Gene Expression Regulation*
Genes, Recessive*
Lens, Crystalline / cytology,  embryology

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