Document Detail


Expression of mortalin in patients with chronic atrial fibrillation.
MedLine Citation:
PMID:  15309412     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In myocardium of patients with chronic atrial fibrillation (AF) the expression of the mitochondrial heat shock proteins HSP60 and HSP10 is increased. They are responsible for folding and translocation of proteins inside the mitochondria. Import of these proteins is accomplished by mortalin. The aim of our study was to investigate if the expression of the heat shock protein mortalin is also increased in patients with AF. METHODS: Right atrial samples from 18 patients undergoing elective cardiac surgery were excised and immediately frozen in liquid nitrogen: 8 patients had chronic AF (> or = 3 month) and 10 patients were in sinus rhythm (SR). Mortalin was determined by SDS-PAGE, Western blot and quantified by optical densitometry. RESULTS: In myocardial samples from patients with chronic AF we found a more than 2-fold increase in mortalin expression. CONCLUSIONS: The increased expression of mortalin may represent an adaptive heat shock response to restore cellular homeostasis.
Authors:
Kiriakos Kirmanoglou; Andreas Hannekum; Alfons E Schäfler
Publication Detail:
Type:  Journal Article     Date:  2004-05-05
Journal Detail:
Title:  Basic research in cardiology     Volume:  99     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-25     Completed Date:  2005-10-28     Revised Date:  2007-07-25    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  404-8     Citation Subset:  IM    
Affiliation:
Department of Cardiac Surgery, University of Ulm, Steinhövelstr. 9, 89075 Ulm, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Atrial Fibrillation / metabolism*
Chronic Disease
Coronary Artery Bypass
Female
Gene Expression Regulation*
HSP70 Heat-Shock Proteins / metabolism*
Humans
Male
Middle Aged
Myocardium / metabolism*
Chemical
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins; 0/HSPA9 protein, human; 0/mortalin

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