Document Detail


Expression of mitotic Aurora/Ipl1p-related kinases in renal cell carcinomas: an immunohistochemical study.
MedLine Citation:
PMID:  13680024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Aurora/Ipl1p-related kinases, AIRK1, AIRK2 and AIRK3, are members of a novel family of oncogenic serine/threonine kinases regulated by cell cycle progression and involved in chromosome segregation and cytokinesis. In this study, we examined expression of members of the AIRK family in human renal cell carcinomas. Expression of AIRK subfamilies was examined in 64 renal cell carcinomas by immunohistochemistry. Immunostaining of AIRK1, AIRK2 and AIRK3 was observed in 95%, 47% and 98% of specimens, respectively. Moreover, in specimens from the same patient, staining of AIRK2 was correlated with proliferating cell nuclear antigen labeling. Here we provide the first description of AIRK isozyme immunostaining in human renal cell carcinoma. Although the precise physiological functions of these kinases are not known, AIRK subfamily expression may play a role in renal cell carcinoma tumorigenesis.
Authors:
Hidetoshi Ehara; Shigeaki Yokoi; Masayoshi Tamaki; Yoshinori Nishino; Yoshito Takahashi; Takashi Deguchi; Masashi Kimura; Takashi Yoshioka; Yukio Okano
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Publication Detail:
Type:  Journal Article     Date:  2003-09-13
Journal Detail:
Title:  Urological research     Volume:  31     ISSN:  0300-5623     ISO Abbreviation:  Urol. Res.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-09-02     Revised Date:  2011-07-11    
Medline Journal Info:
Nlm Unique ID:  0364311     Medline TA:  Urol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  382-6     Citation Subset:  IM    
Affiliation:
Department of Urology, Gifu University School of Medicine, 40 Tsukasa, Gifu 500-8705, Japan. h-ehara@cc.gifu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Renal Cell / chemistry*,  pathology
Cohort Studies
Humans
Immunohistochemistry / methods
Kidney Neoplasms / chemistry*,  pathology
Mitosis
Proliferating Cell Nuclear Antigen / analysis
Protein Isoforms / analysis
Protein-Serine-Threonine Kinases / analysis*
Staining and Labeling
Tissue Distribution
Chemical
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen; 0/Protein Isoforms; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/aurora kinase

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