Document Detail


Expression of the mid-stage differentiation B-cell antigen GP-70 in patients with early and stable form of B-CLL.
MedLine Citation:
PMID:  3089925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of B-cell surface markers SmIg and GP-70 was determined on the mononuclear cells from the peripheral blood of 25 patients with chronic lymphocytic leukemia (CLL), 10 patients with multiple myeloma (MM), 6 normal blood donors and in 3 cases of unexplained persistent lymphocytosis. GP-70 was expressed only in CLL patients whereas multiple myeloma patients, blood donors and patients with unexplained lymphocytosis were all negative to GP-70. SmIg was expressed in CLL patients and in some of the multiple myeloma patients. Subgrouping of CLL patients to "early", stable patients (10) and to more advanced CLL patients (15) revealed differential expression of GP-70 on CLL cells from patients with more advanced stage of disease rather than in the patients with the "early" stable clinical course of disease. SmIg, on the other hand, was expressed equally on both subgroups of CLL. Furthermore, in some cases (25%) where SmIg and the light chains of Ig were only weakly expressed or were absent, GP-70 was markedly expressed. These findings suggest that GP-70 can be used as a single laboratory determination to establish clonality of the B-lymphocyte proliferation in CLL. In addition, expression of GP-70 correlates with significant clinical parameters of the disease.
Authors:
Y Gazitt; E Malamud; M Elgat; D Meytes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology letters     Volume:  12     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-09-22     Completed Date:  1986-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Antigens, Differentiation, B-Lymphocyte
Antigens, Neoplasm / immunology*
Antigens, Surface / immunology*
B-Lymphocytes / immunology*
Cell Differentiation
Clone Cells / immunology
Female
Humans
Leukemia, Lymphoid / classification,  immunology*
Male
Middle Aged
Receptors, Antigen, B-Cell / immunology
Chemical
Reg. No./Substance:
0/Antigens, Differentiation, B-Lymphocyte; 0/Antigens, Neoplasm; 0/Antigens, Surface; 0/Receptors, Antigen, B-Cell

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