Document Detail

Expression of metallothionein-III and cell death in differentiated catecholaminergic neuronal cells.
MedLine Citation:
PMID:  15327758     Owner:  NLM     Status:  MEDLINE    
Metallothionein (MT)-III, an isomer of metallothionein, is also known to be a growth inhibitory factor. MT-III has been reported to decrease the number of surviving neuronal cells in culture medium containing brain extract. Using differentiated catecholaminergic neuronal CATH.a cells treated with dibutyryl cyclic AMP, we examined MT-III expression and the effect of mouse forebrain extract on cell viability. Increase in MT-III expression was revealed in the differentiated cells. Moreover, treatment with mouse forebrain extract induced apoptotic cell death in differentiated CATH.a cells, accompanied by decreases in both MT-III and a neuronal differentiation marker, growth-associated protein-43, expression in surviving cells. These results imply that MT-III expression during the developmental period may be associated with the regulation of normal neural differentiation.
Youichirou Higashi; Masato Asanuma; Ikuko Miyazaki; Norio Ogawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurological research     Volume:  26     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-25     Completed Date:  2005-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  671-6     Citation Subset:  IM    
Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan.
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MeSH Terms
Catecholamines / analysis,  biosynthesis*
Cell Death / physiology
Cell Differentiation / drug effects,  physiology*
Cyclic AMP / pharmacology
Dose-Response Relationship, Drug
Gene Expression Regulation / drug effects,  physiology
Metallothionein / analysis,  biosynthesis
Mice, Inbred ICR
Nerve Tissue Proteins / analysis,  biosynthesis*
Neurons / chemistry,  drug effects,  metabolism*
Reg. No./Substance:
0/Catecholamines; 0/Nerve Tissue Proteins; 0/growth inhibitory factor; 60-92-4/Cyclic AMP; 9038-94-2/Metallothionein

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