| Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in head and neck squamous cell carcinoma. | |
| | |
MedLine Citation:
|
PMID: 9109715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes implicated in the invasion and metastasis of many cancers. In situ hybridization techniques were used to reveal sites of expression of collagenase (MMP-1), gelatinase 72 kd (MMP-2), gelatinase 92 kd (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in head and neck carcinomas (N = 21). Both TIMP-1 and gelatinase 72 kd were expressed in nearly all tumors, whereas the expression of collagenase and gelatinase 92 kd showed variability. Tumor-associated expression of MMPs was strongest in stromal cells near advancing margins. No differences in expression levels were detected between primary and metastatic sites. This paper reviews the literature and discusses the significance and possible implications of MMPs in head and neck squamous cell carcinoma. |
| | |
Authors:
|
S J Charous; G P Stricklin; L B Nanney; J L Netterville; B B Burkey |
Related Documents
:
|
19570695 - Immunohistochemical expression of matrilysins (mmp-7 and mmp-26) in ameloblastomas and ... 9337525 - Plasminogen activators and plasmin in lung cancer. 10362135 - Nitric-oxide production by murine mammary adenocarcinoma cells promotes tumor-cell inva... 23237555 - The tumor microenvironment: a target for combination therapy of breast cancer. 18601555 - Pulsed diode laser-based monitor for singlet molecular oxygen. 9794995 - Radioprotectants: pharmacology and clinical applications of amifostine. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The Annals of otology, rhinology, and laryngology Volume: 106 ISSN: 0003-4894 ISO Abbreviation: Ann. Otol. Rhinol. Laryngol. Publication Date: 1997 Apr |
Date Detail:
|
Created Date: 1997-05-08 Completed Date: 1997-05-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0407300 Medline TA: Ann Otol Rhinol Laryngol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 271-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Carcinoma, Squamous Cell / enzymology*, metabolism, pathology* Collagenases / antagonists & inhibitors, metabolism DNA Primers Gelatinases / metabolism Gene Amplification Gene Expression Glycoproteins / metabolism Head and Neck Neoplasms / enzymology*, metabolism, pathology Histocytochemistry Humans In Situ Hybridization Matrix Metalloproteinase 1 Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Metalloendopeptidases / biosynthesis, metabolism* Middle Aged Neoplasm Staging Polymerase Chain Reaction Tissue Inhibitor of Metalloproteinases |
| Chemical | |
Reg. No./Substance:
|
0/DNA Primers; 0/Glycoproteins; 0/Tissue Inhibitor of Metalloproteinases; EC 3.4.24.-/Collagenases; EC 3.4.24.-/Gelatinases; EC 3.4.24.-/Metalloendopeptidases; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9; EC 3.4.24.7/Matrix Metalloproteinase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vocal function following vertical hemilaryngectomy: comparison of four reconstruction techniques in ...
Next Document: Acoustic measurement of change in voice quality with treatment for chronic posterior laryngitis.