| Expression of matrix metalloproteinase-9 (MMP-9) and blood vessel density in laryngeal squamous cell carcinomas. | |
| | |
MedLine Citation:
|
PMID: 20873997 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
CONCLUSION: In this study we found that inflammatory cells may be a source of MMP-9 in laryngeal cancer. MMP-9 was correlated with blood vessel density. MMP-9 may be a potential target to disrupt tumor neovascularization. OBJECTIVE: To study the expression of MMP-9 in laryngeal cancer and determine a possible relation with blood vessel density. METHODS: Immunohistochemistry was used for MMP analysis and for blood vessel detection in 83 laryngeal cancer samples. The density of blood vessels was analyzed with a stereological tool. RESULTS: MMP-9 was detected in inflammatory cells. Positivity for MMP-9 correlated significantly with the grade of differentiation (p = 0.025). Expression of MMP-9 was not correlated with T stage, nodal metastasis, or tumor recurrence. The mean blood vessel density was 51.4 vessels/mm². Specimens were more likely to exhibit higher density of blood vessels when MMP-9 expression was also present (p = 0.014). |
| | |
Authors:
|
Claus Wittekindt; Nebojsa Jovanovic; Orlando Guntinas-Lichius |
Related Documents
:
|
9317427 - Oxygen transport in marine green turtle (chelonia mydas) hatchlings: blood viscosity an... 16732297 - Permeability properties of tumor surrogate blood vessels induced by vegf-a. 6643937 - Benign cavernous hemangioma of the ankle. 16548687 - Feasibility of vitrification as a storage method for tissue-engineered blood vessels. 18197147 - The peritoneum as a novel oxygenation organ: revitalization of intraperitoneal oxygenat... 17626837 - Local vasoconstriction in spinal cord-injured and able-bodied individuals. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-27 |
Journal Detail:
|
Title: Acta oto-laryngologica Volume: 131 ISSN: 1651-2251 ISO Abbreviation: Acta Otolaryngol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: England |
Other Details:
|
Languages: eng Pagination: 101-6 Citation Subset: IM |
Affiliation:
|
Department of Otorhinolaryngology, Justus Liebig University, Giessen, Germany. claus.wittekindt@hno.med.uni-giessen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Implementation and validation of an extraction course using mannequin models for undergraduate denta...
Next Document: A radiofrequency vs topical steroid treatment of chronic nasal obstruction: A prospective randomized...