Document Detail


Expression of the major rheumatoid factor cross-reactive idiotype in pediatric patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  2070569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rheumatoid factor cross-reactive idiotype (RF-CRI) is expressed in high concentrations in the sera of some patients with rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA). To determine if RF-CRI is specifically expressed in rheumatic disease or if it is secondary to polyclonal B-cell activation, we examined sera of 23 children with SLE, 16 adolescents with infectious mononucleosis (IM), and age-matched pediatric controls for RF-CRI expression. Concentrations of RF-CRI in serum, determined by an inhibition ELISA, were 24 +/- 17 micrograms/ml (mean +/- SD) in 25 normal children, 31 +/- 17 in 16 young adults with IM, and were significantly increased, 70 +/- 80 micrograms/ml, in the 23 children with SLE (p less than 0.036). Eleven of 23 SLE patients had serum RF-CRI greater than the mean +/- 2 SD for normal children. Ten of 23 SLE sera contained IgM rheumatoid factor (RF) activity. One patient with IM had a borderline elevated RF-CRI level, and 5 IM patients had RF in their sera. The serum IgM concentrations in sera were: SLE (192 +/- 93 mg/dl) and IM (234 +/- 77 mg/dl) sera. These levels were significantly elevated compared to controls (132 +/- 44 mg/dl), p less than 0.031 for SLE and p less than 0.001 for IM, suggesting that polyclonal activation of B cells was present in SLE and IM patient groups. Increased expression of RF-CRI in the SLE patients correlated directly with high titer anti-DNA antibody values (r = 0.3965, p less than 0.05) and RF activity when human IgG (r = 0.5026, p less than 0.05) was used as the RF binding substrate and inversely with serum C3 levels (r = 0.3925, p less than 0.05). RF-CRI expression did not correlate with RF that bound rabbit (r = 0.3123, p greater than 0.05). Increased serum RF-CRI expression is not a result of polyclonal B-cell activation. RF-CRI may be selectively up-regulated in patients with SLE.
Authors:
V R Bonagura; N T Ilowite; L Hatam; D J Valacer; J F Wedgwood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical immunology and immunopathology     Volume:  60     ISSN:  0090-1229     ISO Abbreviation:  Clin. Immunol. Immunopathol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-20     Completed Date:  1991-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0356637     Medline TA:  Clin Immunol Immunopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  232-43     Citation Subset:  IM    
Affiliation:
Division of Allergy/Immunology, Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies, Anti-Idiotypic / analysis
Antibodies, Antinuclear / analysis
Child
Complement C3c / analysis
Complement C4 / analysis
Cross Reactions
DNA / immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin Idiotypes / analysis
Immunoglobulin M / analysis
Infectious Mononucleosis / immunology
Lupus Erythematosus, Systemic / immunology*
Male
Rheumatoid Factor / analysis*
Chemical
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Antibodies, Antinuclear; 0/Complement C4; 0/Immunoglobulin Idiotypes; 0/Immunoglobulin M; 80295-44-9/Complement C3c; 9007-49-2/DNA; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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