Document Detail


Expression of mRNAs for neurotrophins and their receptors in the rat choroid plexus and dura mater.
MedLine Citation:
PMID:  8580426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of the neurotrophin, nerve growth factor, brain derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 (NGF, BDNF, NT-3 and NT-4) and their receptors of the tyrosine kinase family (trkA, trkB and trkC) have been investigated in the choroid plexus and dura mater of the adult rat by ribonuclease protection assay. The choroid plexus contained high levels of mRNAs for NGF and NT-4, and low levels of NT-3 and BDNF mRNA; and high levels of trkB mRNA, and undetectable levels of trkA and trkC mRNA. In the dura mater there were high levels of NT-3 and NGF, and low levels of BDNF and NT-4 mRNAs; and high levels of trkC mRNA, and relatively high amount of trkB mRNA, while levels of trkA mRNA was undetectable. The present analysis revealed a different distribution of neurotrophins and their related receptors in the choroid plexus and dura mater.
Authors:
T Timmusk; G Mudò; M Metsis; N Belluardo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  6     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-19     Completed Date:  1996-03-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1997-2000     Citation Subset:  IM    
Affiliation:
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Choroid Plexus / metabolism*
Dura Mater / metabolism*
Gene Expression / genetics
Male
Nerve Growth Factors / metabolism*
Protein-Tyrosine Kinases / metabolism
RNA, Messenger / metabolism*
Rats
Rats, Wistar
Receptors, Nerve Growth Factor / metabolism*
Chemical
Reg. No./Substance:
0/Nerve Growth Factors; 0/RNA, Messenger; 0/Receptors, Nerve Growth Factor; EC 2.7.10.1/Protein-Tyrosine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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