Document Detail

Expression of low-molecular-weight neurofilament (NF-L) mRNA during postnatal development of the mouse brain.
MedLine Citation:
PMID:  7477677     Owner:  NLM     Status:  MEDLINE    
A regional Northern blot analysis demonstrated that the highest levels of NF-L mRNA in the adult mouse brain are present in brain stem followed by mid-brain, with lower levels found in neocortex, cerebellum, and hippocampus. The study was extended to the cellular level over course of postnatal development using in situ hybridization. This developmental analysis revealed that the expression of NF-L mRNA closely follows the differentiation pattern of many large neurons during postnatal neurogenesis. Neurons which differentiate early such as Purkinje, mitral, pyramidal, and large neurons of brain stem and thalamic nuclei, expressed high levels of NF-L mRNA at postnatal day 1. Early expression of NF-L mRNA may be required for the maintenance of the extensive neurofilament protein networks that are detected within the axons of larger neurons. Smaller neurons which differentiate later, such as dentate gyrus granule cells, small pyramidal and granule cells of the neocortex, and granule cells of the cerebellum, exhibit a delayed expression of NF-L mRNA.
R Kure; I R Brown
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemical research     Volume:  20     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-12-15     Completed Date:  1995-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  833-46     Citation Subset:  IM    
Department of Zoology, University of Toronto, Ontario, Canada.
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MeSH Terms
Aging / metabolism*
Blotting, Northern
Brain / growth & development,  metabolism*
Brain Stem / metabolism
Cerebellum / metabolism
Cerebral Cortex / metabolism
Gene Expression*
Hippocampus / metabolism
In Situ Hybridization
Mesencephalon / metabolism
Mice, Inbred Strains
Molecular Weight
Neurofilament Proteins / biosynthesis*
Neurons / metabolism*,  physiology
Organ Specificity
RNA, Messenger / biosynthesis*
Sulfur Radioisotopes
Reg. No./Substance:
0/Neurofilament Proteins; 0/RNA, Messenger; 0/Sulfur Radioisotopes; 0/neurofilament protein L

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