| Expression of low-molecular-weight neurofilament (NF-L) mRNA during postnatal development of the mouse brain. | |
| | |
MedLine Citation:
|
PMID: 7477677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A regional Northern blot analysis demonstrated that the highest levels of NF-L mRNA in the adult mouse brain are present in brain stem followed by mid-brain, with lower levels found in neocortex, cerebellum, and hippocampus. The study was extended to the cellular level over course of postnatal development using in situ hybridization. This developmental analysis revealed that the expression of NF-L mRNA closely follows the differentiation pattern of many large neurons during postnatal neurogenesis. Neurons which differentiate early such as Purkinje, mitral, pyramidal, and large neurons of brain stem and thalamic nuclei, expressed high levels of NF-L mRNA at postnatal day 1. Early expression of NF-L mRNA may be required for the maintenance of the extensive neurofilament protein networks that are detected within the axons of larger neurons. Smaller neurons which differentiate later, such as dentate gyrus granule cells, small pyramidal and granule cells of the neocortex, and granule cells of the cerebellum, exhibit a delayed expression of NF-L mRNA. |
| | |
Authors:
|
R Kure; I R Brown |
Related Documents
:
|
22239687 - Epigenetic regulation of myofibroblast differentiation and extracellular matrix product... 22156747 - Integrated regulation of pikk-mediated stress responses by aaa+ proteins ruvbl1 and ruv... 21866277 - Tgfβ superfamily signaling regulators are differentially expressed in the developing a... 9814817 - Id1, id2, and id3 gene expression in neural cells during development. 22503847 - Intratracheal administration of p38α short-hairpin rna plasmid ameliorates lung ischem... 22239687 - Epigenetic regulation of myofibroblast differentiation and extracellular matrix product... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neurochemical research Volume: 20 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 1995 Jul |
Date Detail:
|
Created Date: 1995-12-15 Completed Date: 1995-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 833-46 Citation Subset: IM |
Affiliation:
|
Department of Zoology, University of Toronto, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
metabolism* Animals Autoradiography Blotting, Northern Brain / growth & development, metabolism* Brain Stem / metabolism Cerebellum / metabolism Cerebral Cortex / metabolism Gene Expression* Hippocampus / metabolism In Situ Hybridization Mesencephalon / metabolism Mice Mice, Inbred Strains Molecular Weight Neurofilament Proteins / biosynthesis* Neurons / metabolism*, physiology Organ Specificity RNA, Messenger / biosynthesis* Sulfur Radioisotopes |
| Chemical | |
Reg. No./Substance:
|
0/Neurofilament Proteins; 0/RNA, Messenger; 0/Sulfur Radioisotopes; 0/neurofilament protein L |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alteration of opioid peptide concentrations in the rat pituitary following survivable closed head in...
Next Document: Endogenous excitatory amino acid release from brain slices and astrocyte cultures evoked by trimethy...