Document Detail

Expression and localization of growth factors during mammary gland development.
MedLine Citation:
PMID:  10959406     Owner:  NLM     Status:  MEDLINE    
Growth and differentiation of the mammary gland during development and lactation are controlled by complex hormonal mechanisms. Additionally growth factors are supposed to act as local mediators of the hormonally controlled developmental processes. Mammary tissue for this study was obtained from non pregnant control heifers, primigravid heifers (second part of pregnancy), around parturition, during lactation (early and late) and from dry cows. Using RT-PCR and ribonuclease protections assay (RPA) the expression of the following growth factors was studied in the different phases bovine mammary gland development: Insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), fibroblast growth factor 1 (FGF-I), fibroblast growth factor 2 (FGF-2), transforming growth factor alpha (TGF-alpha). Additionally the expression of fibroblast growth factor receptor (FGFR) and growth hormone receptor (GHR) was investigated. The cellular distribution pattern of several of these growth factors and GHR was obtained using Immunocytochemical techniques. The detailed expression and localization pattern of these growth factors are presented and their role in the local regulation of the bovine mammary gland is briefly discussed.
F Sinowatz; D Schams; A Plath; S Kölle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  480     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-01     Completed Date:  2000-12-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Institute of Veterinary Anatomy, University of Munich, Germany.
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MeSH Terms
Growth Substances / biosynthesis*
Mammary Glands, Animal / physiology*
Pregnancy, Animal / physiology*
Receptors, Fibroblast Growth Factor / biosynthesis
Receptors, Somatotropin / biosynthesis
Reg. No./Substance:
0/Growth Substances; 0/Receptors, Fibroblast Growth Factor; 0/Receptors, Somatotropin

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