| Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals. | |
| | |
MedLine Citation:
|
PMID: 20633639 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The R3 subtype of receptor-type protein tyrosine phosphatases (RPTPs) includes VE-PTP, DEP-1, PTPRO, and SAP-1. All of these enzymes share a similar structure, with a single catalytic domain and putative tyrosine phosphorylation sites in the cytoplasmic region and fibronectin type III-like domains in the extracellular region. The expression of each R3 RPTP is largely restricted to a single or limited number of cell types, with VE-PTP and DEP-1 being expressed in endothelial or hematopoietic cells, PTPRO in neurons and in podocytes of the renal glomerulus, and SAP-1 in gastrointestinal epithelial cells. In addition, these RPTPs are localized specifically at the apical surface of polarized cells. The structure, expression, and localization of the R3 RPTPs suggest that they perform tissue-specific functions and that they might act through a common mechanism that includes activation of Src family kinases. In this review, we describe recent insights into R3-subtype RPTPs, particularly those of mammals. |
| | |
Authors:
|
Takashi Matozaki; Yoji Murata; Munemasa Mori; Takenori Kotani; Hideki Okazawa; Hiroshi Ohnishi |
Related Documents
:
|
19056869 - Loss of sprouty1 rescues renal agenesis caused by ret mutation. 15192089 - Regulation of insulin signaling through reversible oxidation of the protein-tyrosine ph... 10675529 - Nitric oxide donors, nitrosothiols and mitochondrial respiration inhibitors induce casp... 19053769 - Synthesis, modeling, and ret protein kinase inhibitory activity of 3- and 4-substituted... 9600099 - Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein ty... 12932439 - The involvement of calcineurin in acetylcholine receptor redistribution in muscle. 12753909 - Heregulin and her2 signaling selectively activates c-src phosphorylation at tyrosine 215. 11862109 - Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases. 11739169 - A cytoplasmic serine protein kinase binds and may regulate the fanconi anemia protein f... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-12 |
Journal Detail:
|
Title: Cellular signalling Volume: 22 ISSN: 1873-3913 ISO Abbreviation: Cell. Signal. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-09-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8904683 Medline TA: Cell Signal Country: England |
Other Details:
|
Languages: eng Pagination: 1811-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-Machi, Maebashi, Gunma 371-8512, Japan. matozaki@showa.gunma-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Jailbreak: oncogene-induced senescence and its evasion.
Next Document: Illumination of mitotic orchestra during cell division: a Polo view.