Document Detail


Expression of lipoprotein-associated phospholipase A(2) in carotid artery plaques predicts long-term cardiac outcome.
MedLine Citation:
PMID:  19689974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The aim was to test the hypothesis that carotid artery plaque expression of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) predicts cardiac events.
METHODS AND RESULTS: Prospective cohort study of 162 consecutive patients undergoing elective carotid endarterectomy. Lipoprotein-associated phospholipase A(2) content was quantified by immunoblotting and lysophosphatidylcholine (lysoPC) by liquid chromatography tandem mass spectrometry. Additional biomolecular profiling by immunoblotting included C-reactive protein, p67phox, and matrix metalloproteinase-2 and -9. Macrophage plaque content was determined by quantitative immunostaining, plaque collagen content by quantitative Sirius red staining. Follow-up for cardiac death and non-fatal acute myocardial infarction was accomplished over a period of 48 +/- 14 months. Expression of Lp-PLA(2) and lysoPC was higher in carotid plaques of patients with than without cardiac events [median 1.6 (25th, 75th percentile 0.9, 2.5) vs. 0.8 (0.5, 2.0), P = 0.01 and 413 (281, 443) vs. 226 (96, 351) mmol/L, P = 0.03]. Smoking and point increase in carotid Lp-PLA(2) expression but no other traditional cardiovascular risk factor, histological or molecular marker remained predictive of cardiac events in the multivariate Cox proportional hazard analyses [HR 3.65 (1.36-9.83), P = 0.01 and HR 1.34 (1.01-1.77), P = 0.039]. Carotid plaque Lp-PLA(2) expression above the median constituted a more than three times higher risk for cardiac events [HR 3.39 (1.13-10.17), P = 0.03].
CONCLUSION: Lipoprotein-associated phospholipase A(2) expression in carotid artery plaques is a predictor of long-term cardiac outcome. The current study supports the concept of atherosclerosis as a systemic disease with multi-focal complications and personalized medicine.
Authors:
Joerg Herrmann; Dallit Mannheim; Christine Wohlert; Daniele Versari; Fredric B Meyer; Joseph P McConnell; Mario Gössl; Lilach O Lerman; Amir Lerman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-08-17
Journal Detail:
Title:  European heart journal     Volume:  30     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-02     Completed Date:  2010-03-30     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  2930-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
1-Alkyl-2-acetylglycerophosphocholine Esterase / metabolism*
Aged
Atherosclerosis / enzymology
Biological Markers / metabolism
C-Reactive Protein / metabolism
Carotid Arteries / enzymology*,  pathology
Carotid Stenosis / enzymology*,  pathology
Endarterectomy, Carotid
Epidemiologic Methods
Female
Humans
Lysophosphatidylcholines / metabolism*
Macrophages / metabolism
Male
Matrix Metalloproteinase 2 / metabolism
Matrix Metalloproteinase 9 / metabolism
Phosphoproteins / metabolism
Grant Support
ID/Acronym/Agency:
DK73608/DK/NIDDK NIH HHS; HL085307/HL/NHLBI NIH HHS; HL092954/HL/NHLBI NIH HHS; HL77131/HL/NHLBI NIH HHS; K24, HL-69840/HL/NHLBI NIH HHS; R01 HL-63911/HL/NHLBI NIH HHS; R01 HL077131/HL/NHLBI NIH HHS; R01 HL077131-06/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lysophosphatidylcholines; 0/Phosphoproteins; 0/neutrophil cytosol factor 67K; 9007-41-4/C-Reactive Protein; EC 3.1.1.47/1-Alkyl-2-acetylglycerophosphocholine Esterase; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9
Comments/Corrections
Comment In:
Eur Heart J. 2009 Dec;30(23):2829-31   [PMID:  19720637 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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