| Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer. | |
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MedLine Citation:
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PMID: 19713703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/OBJECTIVES: Insulin-like growth factor-1 receptor (IGF-1R) displays a key role in tumor transformation and metastasis. It also makes tumor cells more resistant to chemotherapy. The aim of this study was to investigate the correlation between IGF-1R and multidrug resistance-associated protein-1 (MRP-1), and the clinical significance of their expression in gastric carcinoma (GC). METHODS: IGF-1R and MRP-1 expressed in 113 specimens were detected by immunohistochemistry. The correlation between IGF-1R and MRP-1 expression was determined. In addition, the association of their expression with clinicopathological features and survival data of GC was also analyzed. RESULTS: IGF-1R (75.2%) and MRP-1 (69.0%) were frequently expressed in GC. IGF-1R was associated with tumor size, quantity of stroma, depth of wall invasion, lymph node metastasis, TNM stages and differentiation status of GC (p < 0.05). MRP-1 was associated with tumor size, quantity of stroma, lymph node metastasis, distant metastasis and TNM stages (p < 0.05). IGF-1R over-expression positively correlated with MRP-1 over-expression (rp = 0.39, p < 0.01). IGF-1R and MPR-1 over-expression were correlated with poor prognosis of GC (p < 0.01). 102 patients receiving adjuvant FOLFOX-4 chemotherapy who co-expressed IGF-1R/MRP-1 had poor prognosis (p < 0.05). CONCLUSIONS: The levels of co-expression of IGF-1R/MRP-1 in GC may predict the therapeutic effect of chemotherapy and prognosis of GC. |
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Authors:
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Jie Ge; Zhikang Chen; Shaobin Wu; Jinxiang Chen; Xiaoli Li; Jun Li; Jiye Yin; Zihua Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-28 |
Journal Detail:
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Title: Digestion Volume: 80 ISSN: 1421-9867 ISO Abbreviation: Digestion Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: Switzerland |
Other Details:
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Languages: eng Pagination: 148-58 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Department of General Surgery, Xiangya Hospital, Central South University, Changsha, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Combined Chemotherapy Protocols / administration & dosage, therapeutic use Camptothecin / administration & dosage, analogs & derivatives Drug Resistance, Multiple Drug Resistance, Neoplasm Female Fluorouracil / administration & dosage Humans Immunohistochemistry Leucovorin / administration & dosage Lymphatic Metastasis Male Middle Aged Multidrug Resistance-Associated Proteins / metabolism* Prognosis Receptor, IGF Type 1 / metabolism* Stomach Neoplasms / drug therapy, metabolism*, mortality, pathology Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/IFL protocol; 0/Multidrug Resistance-Associated Proteins; 0/multidrug resistance-associated protein 1; 51-21-8/Fluorouracil; 58-05-9/Leucovorin; 7689-03-4/Camptothecin; EC 2.7.10.1/Receptor, IGF Type 1 |
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