Document Detail


Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-alpha.
MedLine Citation:
PMID:  9862418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uptake of oxidized low density lipoprotein (Ox-LDL) and subsequent foam cell transformation have been implicated in early atherogenesis. Although multiple molecules, including class A and B scavenger receptors, have been identified as Ox-LDL receptors, additional receptors may also be involved in this process. Here, we provide evidence that lectin-like Ox-LDL receptor-1 (LOX-1), a novel Ox-LDL receptor initially identified in vascular endothelial cells, is also expressed in macrophages in humans and mice. Expression of LOX-1 can be induced after macrophage-like differentiation in vitro in human peripheral blood monocytes and the related cell line THP-1 cells. Furthermore, LOX-1 expression can also be detected in resident peritoneal macrophages, and can be upregulated by an inflammatory cytokine TNF-alpha. These results suggest that LOX-1 in macrophages may play an important role in Ox-LDL uptake and subsequent foam cell formation in this cell type.
Authors:
H Moriwaki; N Kume; H Kataoka; T Murase; E Nishi; T Sawamura; T Masaki; T Kita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  440     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-01-11     Completed Date:  1999-01-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  29-32     Citation Subset:  IM    
Affiliation:
Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Blotting, Northern
Cell Differentiation / drug effects
Cell Line
Cells, Cultured
Dose-Response Relationship, Drug
Humans
Immunohistochemistry
Lectins
Leukocytes, Mononuclear
Macrophages / drug effects,  metabolism*
Macrophages, Peritoneal
Mice
Monocytes
Receptors, LDL / biosynthesis*,  genetics
Receptors, Oxidized LDL
Reverse Transcriptase Polymerase Chain Reaction
Scavenger Receptors, Class E
Tetradecanoylphorbol Acetate / pharmacology
Tumor Necrosis Factor-alpha / pharmacology*
Up-Regulation
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Lectins; 0/OLR1 protein, human; 0/Olr1 protein, mouse; 0/Receptors, LDL; 0/Receptors, Oxidized LDL; 0/Scavenger Receptors, Class E; 0/Tumor Necrosis Factor-alpha; 16561-29-8/Tetradecanoylphorbol Acetate

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