| Expression of kinin B1 receptors in the spinal cord of streptozotocin-diabetic rat. | |
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MedLine Citation:
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PMID: 15538175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have reported cardiovascular and nociceptive responses after intrathecal injection of kinin B1 receptor (B1R) agonists in the model of streptozotocin (STZ)-diabetic rat (diabetic). The aim of this study was to measure the early up-regulation of B1R binding sites and mRNA in the thoracic spinal cord of diabetic and control rats. Data show significant increases of specific B1R binding sites in the dorsal horn of diabetic rats 2 days (+315%), 7 days (+303%) and 21 days (+181%) after STZ treatment. Levels of mRNA were significantly increased (+68%) at 2 and 7 days but not at 21 days. These data bring the first molecular evidence for an early up-regulation of B1R in the spinal cord of diabetic rat. |
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Authors:
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Brice Ongali; Maria Martha Campos; Mihai Petcu; Donata Rodi; Frank Cloutier; Jean-Guy Chabot; Gaétan Thibault; Réjean Couture |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 15 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-11 Completed Date: 2005-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 2463-6 Citation Subset: IM |
Affiliation:
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Department of Physiology, Université de Montréal, Pavillon Paul-G.-Desmarais, 2960, Chemin de la Tour, Montréal, Québec, H3T 1J4, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Body Weight / physiology Bradykinin / analogs & derivatives*, pharmacokinetics Diabetes Mellitus, Experimental / metabolism* Gene Expression Regulation / drug effects In Situ Hybridization / methods Iodine Isotopes / pharmacokinetics Male Protein Binding / drug effects, physiology RNA, Messenger / metabolism Radiography / methods Rats Rats, Wistar Receptor, Bradykinin B1 / genetics, metabolism* Reverse Transcriptase Polymerase Chain Reaction / methods Spinal Cord / metabolism* Tetrahydroisoquinolines / pharmacokinetics Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Iodine Isotopes; 0/RNA, Messenger; 0/Receptor, Bradykinin B1; 0/Tetrahydroisoquinolines; 138680-92-9/HOE 140, desArg(10)-; 58-82-2/Bradykinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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