| Expression of keratins in cutaneous epithelial tumors and related disorders - distribution and clinical significance. | |
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MedLine Citation:
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PMID: 21323743 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Please cite this paper as: Expression of keratins in cutaneous epithelial tumors and related disorders - distribution and clinical significance. Experimental Dermatology 2010. Abstract: Keratins are a highly diverse family of cytoskeletal proteins and important markers of epithelial cell differentiation. In this review, applying the new keratin nomenclature recently introduced, we summarize and discuss the distribution and significance of keratin patterns in cutaneous epithelial tumors in relation to the epithelial structures of normal human skin. The available literature data show that the analysis of keratin profiles broadens our understanding of the differentiation, nature and histogenetic origin of the various, highly singular epithelial tumors arising in the skin. Moreover, keratins may aid in histological diagnosis and, in certain instances, may be helpful for the recognition of tumor malignancy and aggressiveness. Furthermore, we briefly address the topic of keratin-related skin disorders. |
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Authors:
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Ichiro Kurokawa; Kenzo Takahashi; Ingrid Moll; Roland Moll |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental dermatology Volume: 20 ISSN: 1600-0625 ISO Abbreviation: Exp. Dermatol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: Denmark |
Other Details:
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Languages: eng Pagination: 217-28 Citation Subset: IM |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Dermatology, Mie University Graduate School of Medicine, Mie, Japan Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Hamburg, Germany Institute of Pathology, Philipps University of Marburg, Marburg, Germany. |
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