Document Detail

Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium.
MedLine Citation:
PMID:  8649827     Owner:  NLM     Status:  MEDLINE    
The jun genes (c-jun, jun-B and jun-D) play a role in critical cell functions such as proliferation, differentiation and apoptosis. We documented jun expression at the mRNA and protein level in human ovarian cancer tissues (n=28), surface epithelial cells of normal ovaries (n=14) and ovarian cancer cell lines (n=6). Almost all of ovarian tumors as well as normal ovaries concomitantly express c-jun, jun-B, and jun-D mRNA. Immunohistochemistry was less sensitive and revealed nuclear c-Jun and Jun-B proteins in the malignant epithelial cells of respectively 38% and 11% of ovarian tumors and in the surface epithelium of a normal premenopausal ovary. In cultured ovarian cancer cells, c-jun and jun-B expression is inducible by serum and TPA and is therefore not constitutive. The c-jun and jun-B proteins therefore play a role both in differentiation of the normal ovarian surface epithelium, as well as in the proliferation of epithelial ovarian cancer cells. High jun-B expression relates to a more malignant phenotype both in vitro and in vivo. The jun-D gene is suppressed in ovarian cancer cells as compared to normal ovarian surface epithelial cells in situ and in vitro. Downregulation of jun-D might therefore be part of the malignant ovarian epithelial cell phenotype.
B Neyns; Katesuwanasing; J Vermeij; C Bourgain; B Vandamme; K Amfo; W Lissens; P DeSutter; E Hooghe-Peters; J DeGrève
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncogene     Volume:  12     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-07-25     Completed Date:  1996-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1247-57     Citation Subset:  IM    
Department of Medical Onocolgy and Haematology, Vrije Universiteit, Brussel, Belgium.
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MeSH Terms
3T3 Cells / metabolism,  physiology
Blotting, Northern
Epithelium / metabolism,  physiology
Gene Expression / drug effects
Gene Expression Regulation, Neoplastic / drug effects
Genes, jun*
Ovarian Neoplasms / genetics,  metabolism*
Ovary / metabolism*,  physiology
Proto-Oncogene Proteins c-jun / biosynthesis*
RNA, Messenger / genetics,  metabolism
Reference Values
Tetradecanoylphorbol Acetate / pharmacology
Tumor Cells, Cultured
Reg. No./Substance:
0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger; 16561-29-8/Tetradecanoylphorbol Acetate

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