| Expression of interleukin-23 and its receptors in human squamous cell carcinoma of the oral cavity. | |
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MedLine Citation:
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PMID: 21472205 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Interleukin (IL)-23 is a heterodimeric cytokine comprising IL-12p40 and the recently cloned IL-23-specific p19 subunit. Like IL-12, IL-23 is expressed predominantly by activated dendritic cells and phagocytic cells. Both cytokines induce interferon-γ secretion by T cells, and antagonistically regulate local inflammatory responses in the tumor microenvironment as well as the infiltration of intra-epithelial lymphocytes. Although the expression of IL-23 in various organs has been reported, it is unclear whether IL-23 is expressed in oral cancer. The expression of IL-23 and its receptors was examined in human oral squamous cell carcinoma (HOSCC) cell lines and tissue. IL-23 and its receptor mRNAs and proteins were spontaneously expressed, and IL-23 was increased by TNF-α stimulation in the oral cancer cells. A cell proliferation assay confirmed that IL-23 promotes cell proliferation in oral cancer. The localization of IL-23 protein in HOSCC tissue was examined using immunohistochemistry. A positive reaction for anti-IL-23 antibody was weakly observed in the cytoplasm of inflammatory infiltrating cells and cancer cells in HOSCC tissue. Meanwhile, nuclear factor-κB immunoreactivity was strongly positive in HOSCC tissue, which is particularly consistent with the observation of IL-23-positive cells in SCC tissue. These data suggest that IL-23 plays a significant role in the growth and proliferation of oral cancer. |
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Authors:
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Masakatsu Fukuda; Masahiro Ehara; Seiji Suzuki; Hideaki Sakashita |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular medicine reports Volume: 3 ISSN: 1791-3004 ISO Abbreviation: Mol Med Rep Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2012-10-02 Revised Date: 2013-02-22 |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 89-93 Citation Subset: - |
Affiliation:
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Second Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama 350-0283, Japan. fukudam@dent.meikai.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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