Document Detail

Expression of interleukin-23 and its receptors in human squamous cell carcinoma of the oral cavity.
MedLine Citation:
PMID:  21472205     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Interleukin (IL)-23 is a heterodimeric cytokine comprising IL-12p40 and the recently cloned IL-23-specific p19 subunit. Like IL-12, IL-23 is expressed predominantly by activated dendritic cells and phagocytic cells. Both cytokines induce interferon-γ secretion by T cells, and antagonistically regulate local inflammatory responses in the tumor microenvironment as well as the infiltration of intra-epithelial lymphocytes. Although the expression of IL-23 in various organs has been reported, it is unclear whether IL-23 is expressed in oral cancer. The expression of IL-23 and its receptors was examined in human oral squamous cell carcinoma (HOSCC) cell lines and tissue. IL-23 and its receptor mRNAs and proteins were spontaneously expressed, and IL-23 was increased by TNF-α stimulation in the oral cancer cells. A cell proliferation assay confirmed that IL-23 promotes cell proliferation in oral cancer. The localization of IL-23 protein in HOSCC tissue was examined using immunohistochemistry. A positive reaction for anti-IL-23 antibody was weakly observed in the cytoplasm of inflammatory infiltrating cells and cancer cells in HOSCC tissue. Meanwhile, nuclear factor-κB immunoreactivity was strongly positive in HOSCC tissue, which is particularly consistent with the observation of IL-23-positive cells in SCC tissue. These data suggest that IL-23 plays a significant role in the growth and proliferation of oral cancer.
Masakatsu Fukuda; Masahiro Ehara; Seiji Suzuki; Hideaki Sakashita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular medicine reports     Volume:  3     ISSN:  1791-3004     ISO Abbreviation:  Mol Med Rep     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2011-04-07     Completed Date:  2012-10-02     Revised Date:  2013-02-22    
Medline Journal Info:
Nlm Unique ID:  101475259     Medline TA:  Mol Med Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  -    
Second Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama 350-0283, Japan.
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