Document Detail


Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer.
MedLine Citation:
PMID:  16614887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent experimental evidence has shown a potential role of interleukin (IL)-11 and its receptor in breast cancer development and progression. However, there is little clinical information to support this hypothesis. We examined the expression of IL-11 and its receptor in primary breast cancer tissue samples and correlated their level of expression with the clinical outcome. METHODS: Primary breast cancer samples (n=109) and matched background tissue obtained from patients in the cohort (n=33) were processed for frozen section and RNA extraction. Frozen sections from matched tissues were immunostained with IL-11 and IL-11 receptor antibodies. Staining intensity was analyzed by computer image analysis. RNA was reverse-transcribed and quantified before analysis by quantitative polymerase chain reaction. Results were expressed as the number of transcripts (standardized by beta-actin). The data were compared with the clinical outcome of the disease. RESULTS: The intensity of staining for both IL-11 and the IL-11 receptor was distinctly high in tumor samples (P<.01). The transcript level of IL-11 was significantly higher in node-positive tumor samples compared with node-negative samples (P=.02). Tumors with a poor prognostic index and poor histological grade showed a higher level of IL-11. A higher level of IL-11 was linked to poorer survival with Kaplan-Meier survival analysis. CONCLUSIONS: IL-11 can be a predictor of poor prognosis in human breast cancer.
Authors:
Satheesha Hanavadi; Tracey A Martin; Gareth Watkins; Robert E Mansel; Wen G Jiang
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-04-14
Journal Detail:
Title:  Annals of surgical oncology     Volume:  13     ISSN:  1068-9265     ISO Abbreviation:  Ann. Surg. Oncol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-16     Completed Date:  2006-10-24     Revised Date:  2007-07-18    
Medline Journal Info:
Nlm Unique ID:  9420840     Medline TA:  Ann Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  802-8     Citation Subset:  IM    
Affiliation:
University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, CF4 4XN, United Kingdom. satheeshh@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Breast Neoplasms / diagnosis*,  genetics,  pathology
Case-Control Studies
Female
Frozen Sections
Humans
Immunoenzyme Techniques
Interleukin-11 / genetics,  metabolism*
Interleukin-11 Receptor alpha Subunit
Neoplasm Recurrence, Local / pathology
Prognosis
RNA, Messenger / genetics,  metabolism
Receptors, Interleukin / genetics,  metabolism*
Receptors, Interleukin-11
Reverse Transcriptase Polymerase Chain Reaction
Survival Rate
Chemical
Reg. No./Substance:
0/IL11 protein, human; 0/IL11RA protein, human; 0/Interleukin-11; 0/Interleukin-11 Receptor alpha Subunit; 0/RNA, Messenger; 0/Receptors, Interleukin; 0/Receptors, Interleukin-11

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