Document Detail

Expression of inflammatory cytokines in placentas from pregnancies complicated with preeclampsia and HELLP syndrome.
MedLine Citation:
PMID:  23131093     Owner:  NLM     Status:  Publisher    
Abstract Objective. To investigate expression of tumor necrosis factor-alfa (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) in villous trophoblast, syncytial knots and decidua placentas from pregnancies complicated with preeclampsia (PE), HELLP syndrome and gestational age-matched controls. Methods. Study group included 35 placentas from pregnancies complicated with PE and 35 placentas from pregnancies with HELLP syndrome. Control group included 35 placentas from idiopathic preterm labor. Placentas were matched according to gestational age. Expression of TNF-α, IL-6 and IL-10 was determined by immunohistochemistry and semi quantitative HSCORE method in villous trophoblast, syncytial knots and decidua. Non-parametric statistics were used for analyses. Results. There was no difference in the expression of TNF-α, IL-6, and IL-10 in all studied placental segments between PE, HELLP and gestational age-matched control group. TNF-α (F=32, 41, p<0,001), IL-6 (F=58,53, p<0,001) and IL-10 (F=17,62, p<0,001) expression was significantly different in different placental cell types, the highest expression of cytokines was in decidua. Conclusion. There was no difference in cytokine expression in villous trophoblast, syncytial knots and decidua among studied placental groups. The expression of cytokines was highest in decidua in all studied placental groups.
Jelena Marusic; Ivana Kuzmic Prusac; Sandra Zekic Tomas; Jasminka Resic Karara; Damir Roje
Related Documents :
1030793 - Blood pressure, edema and proteinuria in pregnancy. 8. evaluation of criteria.
1742683 - Detection of the fetus in the cul-de-sac by transabdominal and transvaginal ultrasound....
17289683 - Ultrasound-guided embryo transfer does not offer any benefit in clinical outcome: a ran...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-6
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A first insight into the genotypic diversity of Mycobacterium tuberculosis from Rwanda.
Next Document:  Barriers and Promoters of Home-Based Pasteurization of Breastmilk Among HIV-Infected Mothers in Grea...