Document Detail

Expression of inducible nitric oxide synthase (iNOS) in oral precancer and oral squamous cell carcinoma: An immunohistochemical study.
MedLine Citation:
PMID:  22012771     Owner:  NLM     Status:  In-Data-Review    
Aims: Prolonged production of the free radical, nitric oxide (NO) by the enzyme inducible nitric oxide synthase (iNOS) plays an important role in tumour progression by promoting angiogenesis, invasion and inducing mutation in tumour suppressor gene. The purpose of this study is to evaluate the expression and intensity of iNOS in normal oral mucosa, precancer and oral squamous cell carcinoma (OSCC). Materials and methods: An immunohistochemical study was performed using rabbit monoclonal antibody to iNOS on archival formalin fixed, paraffin embedded tissues of 5 normal oral mucosal samples, 10 Leukoplakia, 10 oral submucous fibrosis (OSMF) and 15 OSCC of different grades. Results: A statistical significant difference was found between normal oral mucosa, precancer and OSCC in expression of iNOS (p value 0.0015). However, there was no statistically significant difference between the expressions of iNOS within premalignant groups (p value 0.5647) and histological sub-groups of OSCC (p value-0.5647). There was no statistically significant difference in the intensity of iNOS expression within the precancer group, OSCC sub-groups and between precancer and OSCC (p value-0.623). Conclusion: The orderly increase in the expression of iNOS from normal, through precancer, to OSCC suggests the essential role played by iNOS in epithelial transformation and tumour formation.
Soma Susan Varghese; P M Sunil; R Nirmal Madhavan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer biomarkers : section A of Disease markers     Volume:  8     ISSN:  1875-8592     ISO Abbreviation:  Cancer Biomark     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2011-10-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256509     Medline TA:  Cancer Biomark     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  IM    
Department of Oral and Maxillofacial Pathology, Mar Baselious Dental College and Hospital, Kothamangalam, Kerala, India.
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