| Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene. | |
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MedLine Citation:
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PMID: 11029491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The serine/threonine protein phosphatase type 5 (PP5) gene expression was ubiquitously observed among all the tissues examined, but being at the lowest level in the liver. The levels of PP5 mRNA were markedly elevated in rat highly malignant ascites hepatomas, while those in several rat primary hepatomas were slightly increased and those in the regenerating livers were not elevated at all compared to the control liver. The PP5 gene was mapped to rat chromosome 1q22.1. This region has been identified to have linkage homology among human, mouse and rat, and is known to be associated with several tumor types. Taken together, the present results strongly suggest important roles of PP5 in tumorigenesis. |
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Authors:
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H Shirato; H Shima; H Nakagama; H Fukuda; Y Watanabe; K Ogawa; Y Matsuda; K Kikuchi |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of oncology Volume: 17 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-12-05 Completed Date: 2000-12-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: GREECE |
Other Details:
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Languages: eng Pagination: 909-12 Citation Subset: IM |
Affiliation:
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Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascites / enzymology, genetics Cell Transformation, Neoplastic / genetics Chromosome Mapping Enzyme Induction Gene Expression Regulation, Neoplastic Humans In Situ Hybridization, Fluorescence Liver Neoplasms, Experimental / chemically induced, enzymology*, genetics Liver Regeneration / genetics Mice Neoplasm Proteins / biosynthesis, genetics* Nuclear Proteins / biosynthesis, genetics* Organ Specificity Phosphoprotein Phosphatases / biosynthesis, genetics* RNA, Messenger / analysis RNA, Neoplasm / analysis Rats Rats, Wistar Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 0/Nuclear Proteins; 0/RNA, Messenger; 0/RNA, Neoplasm; EC 3.1.3.16/Phosphoprotein Phosphatases; EC 3.1.3.16/protein phosphatase 5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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