Document Detail

Expression of immunoreactivities to 75 kDa nerve growth factor receptor, trk gene product and phosphotyrosine in granular cell tumors.
MedLine Citation:
PMID:  8563936     Owner:  NLM     Status:  MEDLINE    
Nineteen granular cell tumors (GCT) of adults, two congenital granular cell epulides and five epulides fibrosae were immunohistochemically examined to detect the expression of 75 kDa nerve growth factor receptor (NGFR), trk gene product, phosphotyrosine (PT), protein gene product 9.5 (PGP9.5) and S-100 protein. The NGFR-immunoreactivity (IR) and trk gene product-IR were expressed on almost all granular cells of GCT. PT-IR was also demonstrated on granular cells of all GCT examined, although the frequency of positive cells was low. Congenital granular cell epulides and epulides fibrosae were negative for NGFR-IR, trk gene product-IR and PT-IR. S-100 protein was localized in granular cells of adult GCT but not in the granular cells of congenital epulis. On the other hand, PGP9.5 was detected in granular cells of both conditions and in fibroblastic cells of epulis fibrosa. The present results further indicate that GCT is of peripheral nerve Schwann cell origin, while the congenital granular cell epulides are not of neural origin. NGFR and trk gene product expressed on GCT seems to be functional in terms of phosphorylation of the tyrosine residue in the receptor or downstream protein in signal transduction.
N Hoshi; Y Tsu-ura; K Watanabe; T Suzuki; R Kasukawa; T Suzuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  45     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-07     Completed Date:  1996-03-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  748-56     Citation Subset:  IM    
Department of Pathology, Fukushima Medical College, Japan.
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MeSH Terms
Cell Membrane / chemistry
Child, Preschool
Colonic Neoplasms / chemistry,  pathology
Cytoplasm / chemistry
Drosophila Proteins*
Esophageal Neoplasms / chemistry,  pathology
Granular Cell Tumor / chemistry*,  congenital,  pathology
Infant, Newborn
Middle Aged
Peripheral Nerves / chemistry
Phosphotyrosine / analysis*
Proteins / analysis*
Receptors, Nerve Growth Factor / analysis*
Skin Neoplasms / chemistry,  pathology
Tongue Neoplasms / chemistry,  pathology
Vulvar Neoplasms / chemistry,  pathology
Reg. No./Substance:
0/Drosophila Proteins; 0/Proteins; 0/Receptors, Nerve Growth Factor; 0/trunk protein, Drosophila; 21820-51-9/Phosphotyrosine

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