| Expression of the high mobility group A family member p8 is essential to maintaining tumorigenic potential by promoting cell cycle dysregulation in LbetaT2 cells. | |
| | |
MedLine Citation:
|
PMID: 17451874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The mechanism by which the HMGA protein p8 facilitates tumorigenesis may be cell cycle dysregulation. Control- (C) LbetaT2 cells, which express p8, form tumors at a rate five-times faster than p8-knockdown (p8-KD)-LbetaT2 cells. In association with this heightened tumorigenic potential, p8-expressing C-LbetaT2 cells avoid G(0)/G(1) arrest and become genetically unstable while p8-KD-LbetaT2 cells arrest in G(0)/G(1), become senescent upon overgrowth, and maintain a diploid population. These phenotypic changes correspond to altered cell cycle regulation at the G(1)-to-S transition that may be due to p8-mediated changes in expression of the Cip/Kip family members of cell cycle inhibitors, p21, p27, and p57. |
| | |
Authors:
|
K M Brannon; C M Million Passe; C R White; N A Bade; M W King; C C Quirk |
Related Documents
:
|
19240714 - Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic ... 15201494 - Effects of hmgb-1 overexpression on cell-cycle progression in mcf-7 cells. 1842794 - Life cycle of simulium jenningsi (diptera: simuliidae) in southern west virginia. 21510844 - Hepatocytic differentiation of rhesus monkey embryonic stem cells promoted by collagen ... 1584994 - Endothelin-1 induces stimulation of prostaglandin synthesis in cells obtained from cani... 20165554 - The role of cell-cell adhesion in the formation of multicellular sprouts. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-23 |
Journal Detail:
|
Title: Cancer letters Volume: 254 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-07-30 Completed Date: 2007-09-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
|
Languages: eng Pagination: 146-55 Citation Subset: IM |
Affiliation:
|
Department of Biology, Indiana University, Bloomington, IN 47405-4401, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blotting, Western Cell Aging / genetics, physiology Cell Cycle / genetics*, physiology Cell Line, Transformed Cell Proliferation Cyclin-Dependent Kinase Inhibitor p21 / genetics, metabolism Cyclin-Dependent Kinase Inhibitor p27 / genetics, metabolism Cyclin-Dependent Kinase Inhibitor p57 / genetics, metabolism DNA-Binding Proteins / genetics*, metabolism G0 Phase / genetics, physiology G1 Phase / genetics, physiology Gene Expression HMGA Proteins / genetics, metabolism Mice Mice, Nude Mutation Neoplasm Proteins / genetics*, metabolism Neoplasms, Experimental / genetics, metabolism, pathology* Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Time Factors beta-Galactosidase / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Cdkn1a protein, mouse; 0/Cdkn1b protein, mouse; 0/Cdkn1c protein, mouse; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Cyclin-Dependent Kinase Inhibitor p57; 0/DNA-Binding Proteins; 0/HMGA Proteins; 0/Neoplasm Proteins; 0/Nupr1 protein, mouse; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27; EC 3.2.1.23/beta-Galactosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cryptogenic localization related epilepsy in children from a tertiary outpatient clinic: is neurolog...
Next Document: Electrolytic recovery of chromium salts from tannery wastewater.