Document Detail


Expression of growth arrest and DNA damage genes and DNA mismatch repair genes in snake melanomas.
MedLine Citation:
PMID:  9827364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Snake melanomas are rare tumours and their pathogenesis is still unclear. In this study the expression of DNA mismatch repair genes and Growth Arrest DNA Damage Genes was investigated. The expression only of 3 of them GADD34, MLH1 and MSH2 was found. The role of these genes in animal tumorigenesis is discussed.
Authors:
M Korabiowska; U Brinck; F L Frye; J C Harshbarger; M Droese; H E Kaiser
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  12     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1999-01-29     Completed Date:  1999-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  539-42     Citation Subset:  IM    
Affiliation:
Department of Cytopathology, Georg August University Göttingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA Damage / genetics*
DNA Repair / genetics*
DNA, Neoplasm / analysis,  genetics*
DNA-Binding Proteins*
Fatal Outcome
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor / genetics*
Melanoma / genetics,  metabolism,  pathology,  veterinary*
MutS Homolog 2 Protein
Neoplasm Proteins / metabolism
Nuclear Proteins
Proteins / metabolism
Proto-Oncogene Proteins / metabolism
Skin Neoplasms / genetics,  metabolism,  pathology,  veterinary*
Snakes*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/DNA-Binding Proteins; 0/Neoplasm Proteins; 0/Nuclear Proteins; 0/Proteins; 0/Proto-Oncogene Proteins; EC 3.6.1.3/MutS Homolog 2 Protein

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