Document Detail

Expression of granulocyte colony-stimulating factor receptor and platelet-derived endothelial cell growth factor in oral and oropharyngeal precancerous lesions.
MedLine Citation:
PMID:  11712784     Owner:  NLM     Status:  MEDLINE    
Epithelial hyperplasia and dysplasia have been diagnosed as precancerous lesions and have been discussed in relationship to carcinogenesis. We analyzed the immunohistochemical expression of granulocyte colony-stimulating factor receptor (G-CSFR) and platelet-derived endothelial cell growth factor (PD-ECGF) in oral and oropharynx; 33 samples of normal epithelium, 28 samples of hyperplasia, 16 samples of dysplasia and 58 samples of squamous cell carcinoma. Also, we examined mean vessel density (MVD) by using CD34 staining and proliferating cell nuclear antigen (PCNA) staining. Dysplasia and head and neck Squamous Cell Carcinoma (SCC) exhibited higher G-CSFR expression and MVD than normal or hyperplastic epithelium (p <0.01). In the PD-ECGF staining, significant differences were found between SCC and normal epithelium, hyperplasia and dysplasia (p<0.001). In dysplasia and hyperplasia, PD-ECGF expression was significantly correlated with PCNA expression (r=0.345, p=0.025), however it was not correlated with the MVD. G-CSFR expression was not correlated with either PCNA or MVD. These results suggest that G-CSFR and PD-ECGF might be concerned with different carcinogenesis pathways of the squamous cells in the oral region and that PD-ECGF may be concerned with epithelial proliferation rather than angiogenesis.
H Sunaga; S Fujieda; H Tsuzuki; K Asamoto; M Fukuda; H Saito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  21     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-11-19     Completed Date:  2001-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  2901-6     Citation Subset:  IM    
Department of Otorhinolaryngology, Fukui Medical University, Japan.
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MeSH Terms
Aged, 80 and over
Antigens, CD34 / analysis
Carcinoma, Squamous Cell / blood supply,  chemistry*
Epithelial Cells / chemistry,  pathology
Leukoplakia / blood supply,  chemistry*
Leukoplakia, Oral / blood supply,  chemistry*
Middle Aged
Mouth Mucosa / chemistry,  pathology*
Mouth Neoplasms / blood supply,  chemistry*
Neoplasm Proteins / analysis
Neovascularization, Pathologic / metabolism
Pharyngeal Neoplasms / blood supply,  chemistry*
Precancerous Conditions / metabolism*
Proliferating Cell Nuclear Antigen / analysis
Receptors, Granulocyte Colony-Stimulating Factor / analysis*
Thymidine Phosphorylase / analysis*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Antigens, CD34; 0/Neoplasm Proteins; 0/Proliferating Cell Nuclear Antigen; 0/Receptors, Granulocyte Colony-Stimulating Factor; 0/Tumor Markers, Biological; EC Phosphorylase

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