| Expression and functional role of β(3) -adrenoceptors in the human ureter. | |
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MedLine Citation:
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PMID: 23360304 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the presence of β-adrenoceptor subtypes in the human ureter, and to examine whether β(3) -adrenoceptors modulate relaxation of the human ureter. METHODS: Expression of messenger ribonucleic acid of β-adrenoceptors in the human ureter was determined by reverse transcription polymerase chain reaction, and distribution of β-adrenoceptors was examined by immunohistochemistry. In functional studies, the relaxant effects of isoproterenol, procaterol, TRK-380, salbutamol and BRL 37344 on KCl-induced contraction of the human ureter were evaluated, and the inhibitory effects of isoproterenol, procaterol and TRK-380 on electrical field stimulation-induced contractions were determined. RESULTS: Expression of β(1) -, β(2) - and β(3) -adrenoceptor messenger ribonucleic acid in the human ureter was confirmed by reverse transcription polymerase chain reaction. Positive staining for β(1) -, β(2) - and β(3) -adrenoceptor was identified not only in smooth muscle, but also in the urothelium of the human ureter. All β-adrenoceptor agonists decreased the tone of KCl-induced contractions of the human ureter with a rank order of relaxant effects of isoproterenol > procaterol > TRK-380 > salbutamol > BRL 37344. Furthermore, isoproterenol, procaterol and TRK-380 significantly decreased the amplitude of electrical field stimulation-induced contractions with a rank order of inhibitory effects of isoproterenol > procaterol > TRK-380. CONCLUSIONS: Human ureteral relaxation is mediated by both β(2) - and β(3) -adrenoceptor stimulation. β(3) -Adrenoceptor agonists have the potential to relax the human ureter, and their clinical application in the treatment of ureteral stones is expected. |
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Authors:
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Rikiya Matsumoto; Atsushi Otsuka; Takahisa Suzuki; Hitoshi Shinbo; Takuji Mizuno; Yutaka Kurita; Soichi Mugiya; Seiichiro Ozono |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-29 |
Journal Detail:
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Title: International journal of urology : official journal of the Japanese Urological Association Volume: - ISSN: 1442-2042 ISO Abbreviation: Int. J. Urol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440237 Medline TA: Int J Urol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2013 The Japanese Urological Association. |
Affiliation:
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Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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